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Mice, Inbred MRL lpr

Known as: Mouse, Inbred MRL lpr, Mice, MRL lpr, MRL lpr Mice 
A mouse substrain that is genetically predisposed to the development of systemic lupus erythematosus-like syndrome, which has been found to be… Expand
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Apoptosis and necroptosis are complementary pathways controlled by common signalling adaptors, kinases and proteases; among these… Expand
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Highly Cited
2010
Highly Cited
2010
Activation of the B-cell antigen receptor (BCR) signaling pathway contributes to the initiation and maintenance of B-cell… Expand
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Highly Cited
1998
Highly Cited
1998
Background genes determine the incidence and severity of lymphoaccumulation and histopathologic manifestations of systemic… Expand
Highly Cited
1998
Highly Cited
1998
CSF-1 and TNF-alpha in the kidney of MRL-Fas(lpr) mice are proximal events that precede and promote autoimmune lupus nephritis… Expand
Highly Cited
1996
Highly Cited
1996
The possible involvement of Fas/APO-1 (CD95) and TNF in antigen-specific AICD of thymocytes and mature T cells has been… Expand
Highly Cited
1996
Highly Cited
1996
To investigate the respective roles of Th1 and Th2 cells in the pathogenesis of lupus-like autoimmune disease, we have analyzed… Expand
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Highly Cited
1994
Highly Cited
1994
MRL-lpr/lpr mice spontaneously develop various manifestations of autoimmunity including an inflammatory arthropathy and immune… Expand
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Highly Cited
1994
Highly Cited
1994
The results presented here provide evidence that the presence of Fas protein in target cells is essential to permit cytotoxicity… Expand
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Highly Cited
1988
Highly Cited
1988
The current study examines the role of the L3T4 T cell subset in the development of lupus-like autoimmunity and… Expand
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Highly Cited
1987
Highly Cited
1987
Polyclonal activation has been proposed as the reason that auto-antibodies are produced during autoimmune disease1–3. This model… Expand