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Methylmalonyl-CoA Mutase

Known as: Mutase, Methylmalonyl-CoA, Methylmalonyl CoA Mutase, Methylmalonyl-CoA Isomerase 
An enzyme that catalyzes the conversion of methylmalonyl-CoA to succinyl-CoA by transfer of the carbonyl group. It requires a cobamide coenzyme. A… 
National Institutes of Health

Related topics

Related topics

10 relations
In BloodMUT geneMethylmalonyl CoA mutase:CCnc:Pt:Ser:QnProcess of secretion

Narrower (1)

Methylmalonic Aciduria due to Methylmalonyl-CoA Mutase Deficiency

Papers overview

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Highly Cited
2006
Highly Cited
2006
Energetics of Interaction between the G-protein Chaperone, MeaB, and B12-dependent Methylmalonyl-CoA Mutase*
MeaB is an auxiliary protein that supports the function of the radical B12-dependent enzyme, methylmalonyl-CoA mutase, although… 
Highly Cited
2006
Highly Cited
2006
Effects of methylmalonyl-CoA mutase gene knockouts on erythromycin production in carbohydrate-based and oil-based fermentations of Saccharopolyspora erythraea
In carbohydrate-based fermentations of Saccharopolyspora erythraea, a polar knockout of the methylmalonyl-CoA mutase (MCM) gene… 
2005
2005
Nitric Oxide Inhibits Mammalian Methylmalonyl-CoA Mutase*
Methylmalonyl-CoA mutase is a key enzyme in intermediary metabolism, and children deficient in enzyme activity have severe… 
2003
2003
Tyrosine 89 accelerates Co-carbon bond homolysis in methylmalonyl-CoA mutase.
The contribution of the active-site residue, Y89, to the trillion-fold acceleration of Co-carbon bond homolysis rate in the… 
1997
1997
Expression and kinetic characterization of methylmalonyl-CoA mutase from patients with the mut- phenotype: evidence for naturally occurring interallelic complementation.
L-Methylmalonyl-CoA mutase (MUT) is an adenosylcobalamin (AdoCbl)-requiring mitochondrial matrix enzyme that catalyzes the… 
Highly Cited
1993
Highly Cited
1993
Cloning, sequencing, and expression of the gene encoding methylmalonyl-coenzyme A mutase from Streptomyces cinnamonensis
In streptomycetes, the conversion of succinyl-coenzyme A (CoA) into methylmalonyl-CoA, catalyzed by methylmalonyl-CoA mutase… 
1990
1990
Adenosylcobalamin-dependent methylmalonyl-CoA mutase from Propionibacterium shermanii. Active holoenzyme produced from Escherichia coli.
The linked structural genes coding for both subunits of adenosylcobalamin-dependent methylmalonyl-CoA mutase from the Gram… 
Highly Cited
1988
Highly Cited
1988
Molecular cloning of L-methylmalonyl-CoA mutase: gene transfer and analysis of mut cell lines.
L-Methylmalonyl-CoA mutase (MCM, EC 5.4.99.2) is a mitochondrial adenosylcobalamin-requiring enzyme that catalyzes the… 
Highly Cited
1982
Highly Cited
1982
Purification and properties of methylmalonyl coenzyme A mutase from human liver.
Highly Cited
1964
Highly Cited
1964
METHYLMALONYL ISOMERASE.IV. PURIFICATION AND PROPERTIES OF THE ENZYME FROM PROPIONIBACTERIA.
Methylmalonyl isomerasel catalyzes the interconversion of methylmalonyl coenzyme A (b) and succinyl coenzyme A (3, 4), a reaction… 
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