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Methylenetetrahydrofolate reductase (NADPH)

Known as: Methylenetetrahydrofolate Reductase, Methylene-THF Reductase (NADPH), MTHFR 
A flavoprotein amine oxidoreductase that catalyzes the reversible conversion of 5-methyltetrahydrofolate to 5,10-methylenetetrahydrofolate. This… 
National Institutes of Health

Related topics

Related topics

16 relations
5,10-Methylenetetrahydrofolate reductase deficiencyEnzyme GeneIn BloodMTHFR gene

Narrower (1)

Mthfr Deficiency, Thermolabile Type

Broader (1)

Oxidoreductase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
The Methylene Tetrahydrofolate Reductase (MTHFR) isoform challenge. High doses of folic acid are not a suitable option compared to 5 Methyltetrahydrofolate treatment
Methylene Tetrahydofolate Reductase (MTHFR) is an enzyme participating to the “folic acid cycle” which is linked to the one… 
2014
2014
Hyperhomocysteinaemia, low folate concentrations and MTHFR C677T mutation in abdominal aortic aneurysm.
BACKGROUND Homocysteine (Hcy) has been implicated in abdominal aortic aneurysm (AAA). However, the association of Hcy, vitamin… 
2010
2010
MTHFR Gene Polymorphism and Its Relationship with Plasma Homocysteine and Folate in a North Indian Population
There is a paucity of data on the prevalence of elevated homocysteine and its relation with plasma folate and the… 
2003
2003
A comparison of the effect of advice to eat either ‘5-a-day’ fruit and vegetables or folic acid-fortified foods on plasma folate and homocysteine
Objective: To assess and compare the effects of natural folate (100 µg) with those of folic acid from fortified sources (100 µg… 
2003
2003
No Association Between the MTHFR Gene Polymorphism and Diabetic Retinopathy in Type 2 Diabetic Patients Without Overt Nephropathy: Response to Maeda et al.
Maeda et al. (1) have recently demonstrated that the presence of the C677T mutation in the methylenetetrahydrofolate reductase… 
1999
1999
Placental Genotyping of the Factor V Leiden, Prothrombin 20210A and the Methylenetetrahydrofolate Reductase (MTHFR) C677T Alleles in IUGR Pregnancies
Placental Genotyping of the Factor V Leiden, Prothrombin 20210A and the Methylenetetrahydrofolate Reductase (MTHFR) C677T Alleles… 
1998
1998
677→CT mutation on the methylenetetrahydrofolate reductase gene is not a risk factor for neural tube defects in Turkey
Editor—Recent studies have shown that periconceptual folic acid supplementation reduces a woman’s risk of having a baby with… 
1997
1997
A common mutation in methylenetetrahydrofolate reductase is an important determinant of hyperhomocysteinemia
Highly Cited
1975
Highly Cited
1975
Folate-dependent 1-carbon transfer to biogenic amines mediated by methylenetetrahydrofolate reductase
IT has been suggested that N-methylation of biogenic amines is involved in the development of certain schizophrenic disorders1,2… 
1968
1968
Tetrahydrofolate-dependent enzyme activities of the rat liver in riboflavin deficiency.
Urinary excretion of formiminoglutamic acid (FIGLU) following an oral, intraperitoneal, intramuscular, or intravenous load with L… 
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