FAQ

Metformin hydrochloride

Known as: 1,1-Dimethylbiguanide Hydrochloride, HCl, Metformin, Hydrochloride, Metformin 
The hydrochloride salt of the biguanide metformin with antihyperglycemic and potential antineoplastic activities. Metformin inhibits complex I (NADPH… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1980-2018
020406019802018

Related topics

Related topics

17 relations

Narrower (10)

AvandametFortametGlucophageGlucovance
(More)
BiguanidesDiabetes Mellitus, Non-Insulin-DependentDrug AllergyKidney Failure
(More)

Broader (1)

Metformin

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Metformin hydrochloride
Drug Allergy
Diabetes Mellitus, Non-Insulin-Dependent
Liver diseases
Metformin
Kidney Failure

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Glucagonlike peptide 1-based therapies and risk of hospitalization for acute pancreatitis in type 2 diabetes mellitus: a population-based matched case-control study.
IMPORTANCE Acute pancreatitis has significant morbidity and mortality. Previous studies have raised the possibility that… (More)
  • table 1
  • table 2
Is this relevant?
2008
2008
Sustained-release matrix tablets of metformin hydrochloride in combination with triacetyl-beta-cyclodextrin.
The low bioavailability and short half-life of metformin hydrochloride (MH) make the development of sustained-release forms… (More)
Is this relevant?
2008
2008
Metformin and the intestine
To the Editor: The antihyperglycaemic effect of metformin is generally attributed to a decrease in hepatic glucose output, with… (More)
Is this relevant?
2008
2008
Simultaneous estimation of metformin hydrochloride, pioglitazone hydrochloride, and glimepiride by RP-HPLC in tablet formulation.
A simple, precise, rapid, and reproducible reversed-phase high-performance liquid chromatography method is developed for the… (More)
Is this relevant?
2008
2008
Simultaneous Estimation of Metformin Hydrochloride and Pioglitazone Hydrochloride by RPHPLC Method from Combined Tablet Dosage Form
A high performance reverse phase liquid chromatographic procedure is developed for simultaneous estimation of metformin… (More)
  • figure 1
  • table 3
  • table 1
  • table 2
Is this relevant?
2006
2006
Preparation and in vitro/in vivo evaluation of sustained-release metformin hydrochloride pellets.
In this study, metformin hydrochloride (MH) sustained-release pellets were successfully prepared by centrifugal granulation. Seed… (More)
Is this relevant?
2004
2004
Adherence to a fixed-dose combination of rosiglitazone maleate/metformin hydrochloride in subjects with type 2 diabetes mellitus: a retrospective database analysis.
BACKGROUND In 2002, fixed-dose combination therapy (FDCT) with rosiglitazone maleate plus metformin hydrochloride became… (More)
Is this relevant?
2004
2004
Rapid and sensitive liquid chromatography-tandem mass spectrometric method for the quantitation of metformin in human plasma.
A rapid and sensitive liquid chromatography-tandem mass spectrometric (LC-MS-MS) method for the determination of metformin in… (More)
Is this relevant?
2003
2003
Psoriasiform drug eruption associated with metformin hydrochloride: a case report.
An 18 year-old-woman presented with a 1-week history of a psoriasiform eruption on her limbs and trunk that began 1 week after… (More)
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Effect of metformin and rosiglitazone combination therapy in patients with type 2 diabetes mellitus: a randomized controlled trial.
CONTEXT Most antidiabetic agents target only 1 of several underlying causes of diabetes. The complementary actions of the… (More)
  • figure 1
  • table 1
  • figure 3
  • figure 4
  • figure 5
Is this relevant?