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Meprin

National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
BackgroundThe metalloprotease meprin β cleaves the Alzheimer’s Disease (AD) relevant amyloid precursor protein (APP) as a… 
Highly Cited
2014
Highly Cited
2014
Significance Mucus with its major constituent, the gel-forming mucins, is important for protecting the host epithelium from… 
Review
2013
Review
2013
The metalloproteases meprin α and meprin β exhibit structural and functional features that are unique among all extracellular… 
Highly Cited
2013
Highly Cited
2013
Type I fibrillar collagen is the most abundant protein in the human body, crucial for the formation and strength of bones, skin… 
Highly Cited
2012
Highly Cited
2012
Background: Meprin β cleaves the amyloid precursor protein. Results: Meprin β-mediated cleavage of the amyloid precursor protein… 
Highly Cited
2011
Highly Cited
2011
Identification of physiologically relevant substrates is still the most challenging part in protease research for understanding… 
Highly Cited
2008
Highly Cited
2008
Interleukin-18 (IL-18), a pro-inflammatory cytokine, is a key factor in inflammatory bowel disease (IBD). Caspase-1 activates… 
Highly Cited
2003
Highly Cited
2003
Meprin A and B, metalloproteases consisting of evolutionarily related α and/or β subunits, are membrane-bound and secreted… 
Highly Cited
2002
Highly Cited
2002
BACKGROUND It has been shown that non-congenic mice strains with lower levels of renal meprin develop less renal injury following… 
Highly Cited
1994
Highly Cited
1994
We have purified to homogeneity the enzyme in the kidney cortex which accounts for the vast majority of matrix-degrading activity…