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Meprin

 
National Institutes of Health

Papers overview

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2016
2016
BackgroundThe metalloprotease meprin β cleaves the Alzheimer’s Disease (AD) relevant amyloid precursor protein (APP) as a… Expand
Highly Cited
2014
Highly Cited
2014
Significance Mucus with its major constituent, the gel-forming mucins, is important for protecting the host epithelium from… Expand
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Review
2013
Review
2013
The metalloproteases meprin α and meprin β exhibit structural and functional features that are unique among all extracellular… Expand
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Highly Cited
2013
Highly Cited
2013
Type I fibrillar collagen is the most abundant protein in the human body, crucial for the formation and strength of bones, skin… Expand
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Highly Cited
2012
Highly Cited
2012
Background: Meprin β cleaves the amyloid precursor protein. Results: Meprin β-mediated cleavage of the amyloid precursor protein… Expand
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Highly Cited
2011
Highly Cited
2011
Identification of physiologically relevant substrates is still the most challenging part in protease research for understanding… Expand
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Highly Cited
2008
Highly Cited
2008
Interleukin-18 (IL-18), a pro-inflammatory cytokine, is a key factor in inflammatory bowel disease (IBD). Caspase-1 activates… Expand
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Highly Cited
2003
Highly Cited
2003
Meprin A and B, metalloproteases consisting of evolutionarily related α and/or β subunits, are membrane-bound and secreted… Expand
Highly Cited
1994
Highly Cited
1994
We have purified to homogeneity the enzyme in the kidney cortex which accounts for the vast majority of matrix-degrading activity… Expand
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1991
1991
The proteinase meprin-A is a disulfide-linked tetramer of 90-kDa glycoprotein subunits. It is expressed at high levels in kidney… Expand