Melarsoprol

Known as: 1,3,2-Dithiarsolane-4-methanol, 2-(4-((4,6-diamino-1,3,5-triazin-2-yl)amino)phenyl)-, Melarsoprol [Chemical/Ingredient] 
Arsenical used in trypanosomiases. It may cause fatal encephalopathy and other undesirable side effects.
National Institutes of Health

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Highly Cited
2012
Highly Cited
2012
The concept of disease-specific chemotherapy was developed a century ago. Dyes and arsenical compounds that displayed selectivity… (More)
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Review
2005
Review
2005
Human African trypanosomiasis (HAT) due to Trypanosoma brucei gambiense or T. b. rhodesiense remains highly prevalent in several… (More)
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2005
2005
Melarsoprol, a water-insoluble drug, is mainly used in the treatment of trypanosomiasis and has demonstrated an in vitro activity… (More)
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2005
2005
Patients with second-stage human African trypanosomiasis treated with eflornithine (n = 251) in 2003 in Kiri, southern Sudan, had… (More)
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2001
2001
Culture adapted T. b. gambiense isolated from Northwest Uganda were exposed to 0.001-0.14 microg/ml melarsoprol or 1.56-100… (More)
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2001
2001
We have analyzed the TbAT1 gene, which codes for the P2 adenosine transporter, from Trypanosoma brucei field isolates to… (More)
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Highly Cited
1999
Highly Cited
1999
Recent data have renewed the interest for arsenic-containing compounds as anticancer agents. In particular, arsenic trioxide… (More)
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Highly Cited
1998
Highly Cited
1998
Inorganic arsenic trioxide (As2O3) and the organic arsenical, melarsoprol, were recently shown to inhibit growth and induce… (More)
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Highly Cited
1997
Highly Cited
1997
Alamar Blue, an indicator for metabolic cell function, was evaluated as a fluorescent and as a colorimetric dye in drug… (More)
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1994
1994
1083 patients with late-stage Trypanosoma brucei gambiense sleeping sickness were treated with melarsoprol in Nioki hospital… (More)
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