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Melarsoprol

Known as: 1,3,2-Dithiarsolane-4-methanol, 2-(4-((4,6-diamino-1,3,5-triazin-2-yl)amino)phenyl)-, Melarsoprol [Chemical/Ingredient] 
Arsenical used in trypanosomiases. It may cause fatal encephalopathy and other undesirable side effects.
National Institutes of Health

Papers overview

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Review
2013
Review
2013
Human African trypanosomiasis, or sleeping sickness, is caused by infection with parasites of the genus Trypanosoma, transmitted… Expand
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Highly Cited
2012
Highly Cited
2012
African trypanosomes cause sleeping sickness in humans, a disease that is typically fatal without chemotherapy. Unfortunately… Expand
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Review
2005
Review
2005
SUMMARY Human African trypanosomiasis (HAT) due to Trypanosoma brucei gambiense or T. b. rhodesiense remains highly prevalent in… Expand
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Highly Cited
2002
Highly Cited
2002
Melaminophenyl arsenical drugs are a mainstay of chemotherapy against late-stage African sleeping sickness, but drug resistance… Expand
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Highly Cited
2000
Highly Cited
2000
BACKGROUND African trypanosomiasis is a fatal disease caused by protozoan parasites of the species Trypanosoma brucei. The… Expand
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Highly Cited
1999
Highly Cited
1999
Recent data have renewed the interest for arsenic-containing compounds as anticancer agents. In particular, arsenic trioxide… Expand
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Highly Cited
1999
Highly Cited
1999
We evaluated the treatment failure rate among late-stage human African trypanosomiasis (HAT) patients treated with melarsoprol in… Expand
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Highly Cited
1998
Highly Cited
1998
Inorganic arsenic trioxide (As 2 O 3 ) and the organic arsenical, melarsoprol, were recently shown to inhibit growth and induce… Expand
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Highly Cited
1997
Highly Cited
1997
Alamar Blue, an indicator for metabolic cell function, was evaluated as a fluorescent and as a colorimetric dye in drug… Expand
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Highly Cited
1997
Highly Cited
1997
Inorganic arsenic trioxide (As2O3) was recently shown to induce apoptosis in NB4 promyelocytic leukemic cells. We have… Expand
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