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Medronic Acid

Known as: Methylenediphosphonic Acid 
A methylene-substituted bisphosphonate. Medronic acid has affinity for and adheres to the surface of hydroxyapatite crystals in the bone matrix. This… 
National Institutes of Health

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3 relations
Medronate Tetrasodiummethylene diphosphonate

Broader (1)

medronate

Papers overview

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2012
2012
Evaluation of Deoxyribonucleic Acid Toxicity Induced by the Radiopharmaceutical 99mTechnetium-Methylenediphosphonic Acid and by Stannous Chloride in Wistar Rats
Radiopharmaceuticals are employed in patient diagnostics and disease treatments. Concerning the diagnosis aspect, technetium-99m… 
2011
2011
HIGHLY EFFICIENT AND VERSATILE ACETYLATION OF ALCOHOLS, PHENOLS AND AMINES CATALYZED BY METHYLENEDIPHOSPHONIC ACID (MDP) UNDER SOLVENT-FREE CONDITIONS
Methylenediphosphonic Acid (MDP) was found to be a simple, cheap and reusable heterogeneous catalyst for the acetylation of… 
1990
1990
[Interaction of dNTP-binding sites of human DNA polymerase alpha and The Klenow fragment of Escherichia coli DNA polymerase I with nucleotides, pyrophosphate and their analogs].
AMP and NaF each taken separately were shown to activate DNA polymerization catalyzed by Klenow fragment of DNA polymerase I by… 
1989
1989
[Analogs of pyrophosphate in a pyrophosphorolysis reaction catalyzed by DNA polymerases].
The reaction of pyrophosphorolysis catalyzed by Escherichia coli DNA polymerase I Klenov fragment, calf thymus DNA polymerase… 
1987
1987
[Effect of diadenosine oligophosphates (Ap4A and Ap3A) and their phosphonate analogs on catalytic properties of phenylalanyl-tRNA synthetase from E. coli].
The influence of P1,P3-bis(5'-adenosyl)triphosphate (Ap3A), P1,P4-bis(5'-adenosyl)tetraphosphate (Ap4A) and its analogues… 
1981
1981
[Pyrophosphate analogs in the pyrophosphorolysis reaction catalyzed by Escherichia coli RNA polymerase].
Processive pyrophosphorolysis of RNA from ternary RNA polymerase-nascent RNA-delta D111 T7 DNA complex has been followed in the… 
1979
1979
A study of the relationship between chemical structure and bone localization of Tc-99m diphosphonic acids: concise communication.
The study was undertaker to evaluate the effect on bone localization of substitutions at the bridge carbon atom of… 
1979
1979
Synthesis and Tc-99m labeling of diisopropyl methylenediphosphonate and comparison of biodistribution versus methylenediphosphonic acid.
1977
1977
[Use of the "graft vs host" reaction to study the immunosuppressive effect of methylenediphosphonic acid].
1976
1976
Guanosine tetraphyosphate and its analogues. Chemical synthesis of guanosine 3',5'-dipyrophosphate, deoxyguanosine 3',5'-dipyrophosphate, guanosine 2',5'-bis(methylenediphosphonate), and guanosine 3…
A new procedure for the synthesis of the pyrophosphate bond has been employed in the preparation of nucleoside dipyrophosphates…