Mediator of activation protein

Known as: Mediator Complex, Mediator Coactivator, Mediator 
A protein complex that is involved in the initiation of transcription. This complex is composed of over 30 protein subunits, which binds to the RNA… (More)
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Master transcription factors Oct4, Sox2, and Nanog bind enhancer elements and recruit Mediator to activate much of the gene… (More)
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Review
2010
Review
2010
The Mediator is an evolutionarily conserved, multiprotein complex that is a key regulator of protein-coding genes. In metazoan… (More)
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Highly Cited
2006
Highly Cited
2006
Components of multiprotein complexes are routinely determined by using proteomic approaches. However, this information lacks… (More)
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Highly Cited
2003
Highly Cited
2003
Hepcidin is a liver-made peptide proposed to be a central regulator of intestinal iron absorption and iron recycling by… (More)
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Highly Cited
2003
Highly Cited
2003
To counteract the continuous exposure of cells to agents that damage DNA, cells have evolved complex regulatory networks called… (More)
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Highly Cited
2002
Highly Cited
2002
IFNalpha/beta, IL-12, and IL-15 regulate NK cell activation and expansion, but signals triggering resolution of the NK response… (More)
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Highly Cited
2002
Highly Cited
2002
53BP1 binds to the tumor suppressor protein p53 and has a potential role in DNA damage responses. We used small interfering RNA… (More)
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Highly Cited
2000
Highly Cited
2000
A critical function of tumor suppressor p53 is the induction of apoptosis in cells exposed to noxious stresses. We report a… (More)
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Highly Cited
1994
Highly Cited
1994
A mediator was isolated from yeast that enabled a response to the activator proteins GAL4-VP16 and GCN4 in a transcription system… (More)
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Highly Cited
1992
Highly Cited
1992
Angiogenic factors produced by monocytes-macrophages are involved in the pathogenesis of chronic inflammatory disorders… (More)
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