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Mecamylamine

Known as: Bicyclo(2.2.1)heptan-2-amine, N,2,3,3-tetramethyl-, Mecamylamine [Chemical/Ingredient] 
A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a… Expand
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
Herein we describe a novel series of compounds from which varenicline (1, 6,7,8,9-tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3… Expand
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Highly Cited
2001
Highly Cited
2001
Because mecamylamine, a nicotinic receptor antagonist, is used so often in nicotine research and because mecamylamine may have… Expand
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Review
2000
Review
2000
Few people now dispute that smoking is damaging human health on a global scale.1 However, many governments have avoided taking… Expand
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Highly Cited
2000
Highly Cited
2000
Nicotinic agonists elicit the release of dopamine from striatal synaptosomes by acting on presynaptic nicotinic acetylcholine… Expand
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Review
1998
Review
1998
Abstract Nicotinic cholinergic systems are involved with several important aspects of cognitive function including attention… Expand
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Highly Cited
1997
Highly Cited
1997
In the present study we investigated electrophysiologically the nicotinic responses of pyramidal neurons and interneurons… Expand
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Highly Cited
1994
Highly Cited
1994
To evaluate concurrent administration of mecamylamine (nicotine antagonist) with nicotine skin patch treatment for smoking… Expand
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Highly Cited
1994
Highly Cited
1994
Stimulation of the mesolimbic dopamine (DA) system is considered of major importance for the rewarding and dependence producing… Expand
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Highly Cited
1984
Highly Cited
1984
Abstract: Characterisation of receptor‐mediated breakdown of inositol phospholipids in rat cortical slices has been performed… Expand
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Highly Cited
1982
Highly Cited
1982
1. Cholinergic drugs were infused into the retinal circulation of the rabbit while we analysed the receptive field properties of… Expand
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