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Matrix Metalloproteinase 3

Known as: procollagenase activator, Metalloproteinase 3, Matrix, MMP3 
An extracellular endopeptidase of vertebrate tissues similar to MATRIX METALLOPROTEINASE 1. It digests PROTEOGLYCAN; FIBRONECTIN; COLLAGEN types III… 
National Institutes of Health

Related topics

Related topics

14 relations
In BloodMMP-3 activityMMP3 geneMMP3 wt Allele

Narrower (1)

MMP3 protein, human

Broader (4)

MetalloendopeptidasesMetalloproteasesmetalloenzymeprogelatinase

Papers overview

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Highly Cited
2000
Highly Cited
2000
Induced expression of dominant‐negative c‐jun downregulates NFκB and AP‐1 target genes and suppresses tumor phenotype in human keratinocytes
Neoplastically transformed mouse and human keratinocytes elevate transactivation of both activator protein 1 (AP‐1) and nuclear… 
Highly Cited
1996
Highly Cited
1996
High levels of stromelysin‐3 correlate with poor prognosis in patients with breast carcinoma
Stromelysin 3 (ST3) is a matrix metalloprotease (MMP) expressed in fibroblast‐like cells of most human invasive carcinomas. In… 
Highly Cited
1995
Highly Cited
1995
Early changes in matrix metalloproteinases and inhibitors after in vitro laser treatment to the trabecular meshwork.
Extracellular matrix turnover in the trabecular meshwork may play a role in regulating aqueous humor outflow. Laser… 
Highly Cited
1994
Highly Cited
1994
Protein restriction reduces transforming growth factor-beta and interstitial fibrosis in nephrotic syndrome.
Nephrotic syndrome induced by puromycin aminonucleoside (PAN) is characterized by tubulointerstitial (TI) inflammation, foci of… 
Review
1994
Review
1994
Degradation of matrix proteins in liver fibrosis.
Highly Cited
1994
Highly Cited
1994
Increased serum proMMP-3 in inflammatory arthritides: a potential indicator of synovial inflammatory monokine activity.
OBJECTIVE--To investigate if the increased concentrations of stromelysin (MMP-3) found in the synovial fluid (SF) of patients… 
Highly Cited
1993
Highly Cited
1993
Differential in vivo expression of collagenase messenger RNA in synovium and cartilage. Quantitative comparison with stromelysin messenger RNA levels in human rheumatoid arthritis and osteoarthritis…
OBJECTIVE To compare quantitatively the in vivo expression of collagenase messenger RNA (mRNA) and stromelysin mRNA in the joint… 
Highly Cited
1993
Highly Cited
1993
Defining the critical gene expression changes associated with expression and suppression of the tumorigenic and metastatic phenotype in Ha-ras-transformed cloned rat embryo fibroblast cells.
Carcinogenesis requires a complex series of genetic changes often involving multiple oncogenes and the inactivation of multiple… 
Highly Cited
1992
Highly Cited
1992
Involvement of AP1 and PEA3 binding sites in the regulation of murine tissue inhibitor of metalloproteinases-1 (TIMP-1) transcription.
Highly Cited
1992
Highly Cited
1992
Expression of matrix metalloproteinase genes in transformed rat cell lines of high and low metastatic potential.
The enzymes that comprise the family of matrix metalloproteinases (MMPs) share the capacity to degrade extracellular matrix… 
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