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MYOCD protein, human

Known as: Myocardin, myocardin protein, human 
Myocardin (938 aa, ~102 kDa) is encoded by the human MYOCD gene. This protein plays a role in myogenesis, heart development and transcriptional… Expand
National Institutes of Health

Related topics

Related topics

13 relations
Cardiac Muscle ContractionCell NucleusDNA-Binding ProteinsGenes, Regulator
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Myocardin regulates mitochondrial calcium homeostasis and prevents permeability transition
Myocardin is a transcriptional co-activator required for cardiovascular development, but also promotes cardiomyocyte survival… Expand
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2017
2017
Upregulation of actin cytoskeleton via myocardin leads to increased expression of type 1 collagen
Liver fibrosis is characterized by excessive deposition of extracellular matrix (ECM) in the liver. Although many fibrogenic cell… Expand
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2016
2016
Myocardin inhibits estrogen receptor alpha-mediated proliferation of human breast cancer MCF-7 cells via regulating MicroRNA expression.
Myocardin is frequently repressed during human malignant transformation, and restoration of myocardin expression in sarcoma cells… Expand
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2015
2015
Protein kinase Cα inhibits myocardin-induced cardiomyocyte hypertrophy through the promotion of myocardin phosphorylation.
Myocardin plays a key role in the development of cardiac hypertrophy. However, the upstream signals that control the stability… Expand
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Highly Cited
2012
Highly Cited
2012
Reciprocal expression of MRTF-A and myocardin is crucial for pathological vascular remodelling in mice.
Myocardin-related transcription factor (MRTF)-A is a Rho signalling-responsive co-activator of serum response factor (SRF). Here… Expand
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2010
2010
Expression and functional activity of four myocardin isoforms.
Myocardin (MYOCD) is an essential component of a molecular switch for the expression of contractile genes in smooth muscle and… Expand
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2010
2010
BAS/BSCR36 Regulation of human smooth muscle cell development by myocardin
Background Myocardin is a cardiac-specific and smooth muscle cell (SMC)-specific transcription factor with a key role in… Expand
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2008
2008
A Rare Human Sequence Variant Reveals Myocardin Autoinhibition*♦
Myocardin (MYOCD) is a transcriptional co-activator that promotes cardiac or smooth muscle gene programs through its interaction… Expand
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Review
2007
Review
2007
Myocardin in Tumor Suppression and Myofibroblast Differentiation
The malignant transformation process is associated with defects in cell cycle regulation and disruption of the normal… Expand
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Highly Cited
2005
Highly Cited
2005
Activation of cardiac and smooth muscle-specific genes in primary human cells after forced expression of human myocardin.
OBJECTIVE Myocardin is a recently discovered transcriptional regulator of cardiac and smooth muscle development. Its ability to… Expand
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