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MYOCD protein, human

Known as: Myocardin, myocardin protein, human 
Myocardin (938 aa, ~102 kDa) is encoded by the human MYOCD gene. This protein plays a role in myogenesis, heart development and transcriptional… 
National Institutes of Health

Related topics

Related topics

13 relations
Cardiac Muscle ContractionCell NucleusDNA-Binding ProteinsGenes, Regulator
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Myocardin regulates mitochondrial calcium homeostasis and prevents permeability transition
Myocardin is a transcriptional co-activator required for cardiovascular development, but also promotes cardiomyocyte survival… 
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2017
2017
Upregulation of actin cytoskeleton via myocardin leads to increased expression of type 1 collagen
Liver fibrosis is characterized by excessive deposition of extracellular matrix (ECM) in the liver. Although many fibrogenic cell… 
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2016
2016
Myocardin inhibits estrogen receptor alpha‐mediated proliferation of human breast cancer MCF‐7 cells via regulating MicroRNA expression
Myocardin is frequently repressed during human malignant transformation, and restoration of myocardin expression in sarcoma cells… 
2015
2015
Protein kinase Cα inhibits myocardin-induced cardiomyocyte hypertrophy through the promotion of myocardin phosphorylation.
Myocardin plays a key role in the development of cardiac hypertrophy. However, the upstream signals that control the stability… 
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Highly Cited
2012
Highly Cited
2012
Reciprocal expression of MRTF‐A and myocardin is crucial for pathological vascular remodelling in mice
Myocardin‐related transcription factor (MRTF)‐A is a Rho signalling‐responsive co‐activator of serum response factor (SRF). Here… 
2010
2010
Expression and functional activity of four myocardin isoforms.
Myocardin (MYOCD) is an essential component of a molecular switch for the expression of contractile genes in smooth muscle and… 
2010
2010
BAS/BSCR36 Regulation of human smooth muscle cell development by myocardin
Background Myocardin is a cardiac-specific and smooth muscle cell (SMC)-specific transcription factor with a key role in… 
2008
2008
A Rare Human Sequence Variant Reveals Myocardin Autoinhibition*♦
Myocardin (MYOCD) is a transcriptional co-activator that promotes cardiac or smooth muscle gene programs through its interaction… 
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Review
2007
Review
2007
Myocardin in Tumor Suppression and Myofibroblast Differentiation
The malignant transformation process is associated with defects in cell cycle regulation and disruption of the normal… 
Highly Cited
2005
Highly Cited
2005
Activation of cardiac and smooth muscle-specific genes in primary human cells after forced expression of human myocardin.
OBJECTIVE Myocardin is a recently discovered transcriptional regulator of cardiac and smooth muscle development. Its ability to… 
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