MUSK gene

Congenital myasthenic syndrome (CMS) is a heterogeneous disorder that causes fatigable muscle weakness. CMS has been associated… (More)

OBJECTIVES To describe the clinical and genetic features of a Chinese congenital myasthenic syndromes (CMS) patient with two… (More)

Myasthenia gravis (MG) is an autoimmune disease characterized by muscle weakness associated with acetylcholine receptor (AChR… (More)

In myasthenia gravis (MG), 5-15% of patients are positive for MuSK antibodies. MuSK binds to LRP4 and transmits an agrin-mediated… (More)

The familial occurrence of autoimmune myasthenia gravis (MG) with anti-acetylcholine receptor antibodies (AChR Ab) has been… (More)

complex interchange of signals to efficiently juxtapose presynaptic release sites with specialized postsynaptic sites. Neuronal… (More)

The receptor tyrosine kinase MuSK is activated by agrin, an extracellular matrix protein believed to be utilized by motoneurons… (More)

Differentiation of the postsynaptic membrane at the neuromuscular junction requires agrin, a nerve-derived signal; MuSK, a… (More)

MuSK is a receptor tyrosine kinase that initiates the formation of neuromuscular junctions in response to agrin. Little is known… (More)

In Drosophila, members of the Frizzled family of tissue-polarity genes encode proteins that appear to function as cell-surface… (More)