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Abstract Primary ovarian insufficiency (POI) is a genetically heterogeneous disorder that occurs in familial or sporadic fashion… Expand OBJECTIVE
Candidate gene and genome-wide association studies have identified several disease susceptibility loci in lupus… Expand BACKGROUND
The mismatch repair proteins MSH5 and MLH3 play a crucial role in spermatogenesis. We tested this hypothesis by… Expand The status of chromatin during spermatogenesis is dynamically regulated by specific histone codes or stage‐specific histone… Expand Ig class switch recombination (CSR) and somatic hypermutation serve to diversify antibody responses and are orchestrated by the… Expand Increasing evidence indicated that the protein factors involved in DNA mismatch repair (MMR) possess meiotic functions beyond the… Expand MSH5 (MutS homologue 5) is a member of a family of proteins known to be involved in DNA mismatch repair. Germline mutations in… Expand MutS homologues have been identified in nearly all organisms examined to date. They play essential roles in maintaining mitotic… Expand Abstract. We have identified and characterized the complete cDNA and gene for the mouse MutS homolog 5 (Msh5), as a step toward… Expand In Saccharomyces cerevisiae the MSH5 gene encoding a MutS homolog was identified as a gene required for meiotic crossing over. To… Expand