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MSH4 protein, human

Known as: MutS Protein Homolog 4, MutS Homolog 4, hMSH4 
MutS protein homolog 4 (936 aa, ~105 kDa) is encoded by the human MSH4 gene. This protein plays a role in reciprocal recombination and proper… Expand
National Institutes of Health

Related topics

Related topics

10 relations

Broader (1)

Cell Cycle Proteins
Cell NucleusDNA RepairDNA Repair GeneDNA repair protein
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2006
2006
Formation of hMSH4-hMSH5 heterocomplex is a prerequisite for subsequent GPS2 recruitment.
Increasing evidence suggests that components of the DNA mismatch repair (MMR) pathway play multifunctional roles beyond the scope… Expand
Highly Cited
2004
Highly Cited
2004
Association between MSH4 (MutS homologue 4) and the DNA strand-exchange RAD51 and DMC1 proteins during mammalian meiosis.
During meiotic prophase, chromosomes must undergo highly regulated recombination events, some of which lead to reciprocal… Expand
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2003
2003
Human MutS homologue MSH4 physically interacts with von Hippel-Lindau tumor suppressor-binding protein 1.
Increasing evidence indicated that the protein factors involved in DNA mismatch repair (MMR) possess meiotic functions beyond the… Expand
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Highly Cited
2002
Highly Cited
2002
The DNA mismatch-repair MLH3 protein interacts with MSH4 in meiotic cells, supporting a role for this MutL homolog in mammalian meiotic recombination.
The mismatch-repair (MMR) system plays a central role in maintaining genetic stability and requires evolutionarily conserved… Expand
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Highly Cited
2000
Highly Cited
2000
MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice.
Msh4 (MutS homolog 4) is a member of the mammalian mismatch repair gene family whose members are involved in postreplicative DNA… Expand
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Highly Cited
2000
Highly Cited
2000
MSH4 acts in conjunction with MLH1 during mammalian meiosis
MSH4 is a meiosis‐specific MutS homolog. In yeast, it is required for reciprocal recombination and proper segregation of… Expand
Highly Cited
1999
Highly Cited
1999
hMSH5: a human MutS homologue that forms a novel heterodimer with hMSH4 and is expressed during spermatogenesis.
MutS homologues have been identified in nearly all organisms examined to date. They play essential roles in maintaining mitotic… Expand
Highly Cited
1997
Highly Cited
1997
Cloning and expression analysis of a meiosis-specific MutS homolog: the human MSH4 gene.
The Escherichia coli MutHLS system has been highly conserved throughout evolution. The eukaryotic pathway results in a… Expand
Highly Cited
1994
Highly Cited
1994
Mutation of a meiosis-specific MutS homolog decreases crossing over but not mismatch correction
MSH4 is a novel meiosis-specific gene required for wild-type levels of spore viability in S. cerevisiae. The predicted product of… Expand
Highly Cited
1989
Highly Cited
1989
Alpha-melanotropin: the minimal active sequence in the lizard skin bioassay.
alpha-Melanotropin (alpha-melanocyte-stimulating hormone, alpha-MSH) is a tridecapeptide, Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp… Expand
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