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MSC1936369
National Institutes of Health
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1 relation
Broader (1)
pimasertib
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Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Abstract LB-208: Hijacking the PI3K/mTor and KRas/MEK/ERK signaling pathways with a therapeutic assault results in robust antitumor activity in PI3K/KRas and KRas mutant tumors
L. Vincent
,
Anne L. Thomas
,
+9 authors
J. Ogden
2011
Corpus ID: 71322476
The PI3K/AKT/mTOR and Ras/Raf/MEK/ERK are interlinked growth and survival signaling pathways both involving regulation by Ras and…
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2010
2010
Preliminary Clinical, Pharmacokinetic (PK) and Pharmacodynamic (PD) Results of the Safety Run-In Part of a Phase II Trial of Orally Available MEK-Inhibitor MSC1936369 in Patients (Pts) with Advanced…
F. Ravandi
,
A. Pigneux
,
+9 authors
B. Smith
2010
Corpus ID: 220867608
Abstract 1554 Background: MSC1936369 is a selective non-competitive inhibitor of MEK1/2 with anti-proliferative activity in…
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2010
2010
374 Clinical, pharmacokinetic (PK) and pharmacodynamic (PD) results of first-in-man phase I trial of the orally available MEK-inhibitor MSC1936369 (AS703026) in patients (pts) with advanced solid…
A. Awada
,
N. Houédé
,
+7 authors
E. Raymond
2010
Corpus ID: 71776998
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