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Signaling by nitric oxide (NO) determines several cardiovascular functions including blood pressure regulation, cardiac and… Expand AIMS
Nitric oxide (NO) and atrial natriuretic peptide (ANP) signalling via cGMP controls smooth muscle tone. One important… Expand Type I cGMP-dependent protein kinases (PKGs) translocate to the nucleus to regulate gene expression in some, but not all cell… Expand cGMP kinase I (cGKI) signaling modulates multiple physiological processes including smooth muscle relaxation. The expression of… Expand Nitric oxide (NO)-mediated relaxation of colonic smooth muscle is crucial for the maintenance of human gut function. The… Expand Cyclic GMP-dependent protein kinase I (cGKI) affects the inositol 1,4,5-trisphosphate (InsP3)-dependent release of intracellular… Expand Over the past few years, a wealth of biochemical and functional data has been gathered on mammalian cGMP-dependent protein… Expand Calcium release from the endoplasmic reticulum controls a number of cellular processes, including proliferation and contraction… Expand The brief of the Organotypic Models Working Group was to review data submitted to the Interagency Regulatory Alternatives Group… Expand