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MRVI1 gene

Known as: Murine Retrovirus Integration Site 1 Homolog Gene, INOSITOL 1,4,5-TRIPHOSPHATE-ASSOCIATED cGMP KINASE SUBSTRATE, murine retrovirus integration site 1 homolog 
This gene plays a role in signal transduction.
National Institutes of Health

Related topics

Related topics

4 relations
MRVI1 protein, humanSignal Transductionprotein protein interaction

Narrower (1)

MRVI1 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2011
Review
2011
IRAG and novel PKG targeting in the cardiovascular system.
Signaling by nitric oxide (NO) determines several cardiovascular functions including blood pressure regulation, cardiac and… 
Highly Cited
2010
Highly Cited
2010
IRAG determines nitric oxide- and atrial natriuretic peptide-mediated smooth muscle relaxation.
AIMS Nitric oxide (NO) and atrial natriuretic peptide (ANP) signalling via cGMP controls smooth muscle tone. One important… 
2010
2010
Cyclic cytidine 3′,5′‐monophosphate (cCMP) signals via cGMP kinase I
Review
2008
Review
2008
ABCD of the phosphodiesterase family: interaction and differential activity in COPD
Phosphodiesterases (PDEs) are important enzymes that hydrolyze the cyclic nucleotides adenosine 3′5′-cyclic monophosphate (cAMP… 
Highly Cited
2007
Highly Cited
2007
IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation.
Defective regulation of platelet activation/aggregation is a predominant cause for arterial thrombosis, the major complication of… 
Highly Cited
2005
Highly Cited
2005
Stressed and depressed
Knocking out a stress hormone receptor in the forebrain of mice generates symptoms of depression, which are alleviated by the… 
Highly Cited
2004
Highly Cited
2004
Distribution of IRAG and cGKI‐isoforms in murine tissues
2004
2004
InsP3R-associated cGMP Kinase Substrate (IRAG) Is Essential for Nitric Oxide-induced Inhibition of Calcium Signaling in Human Colonic Smooth Muscle*
Nitric oxide (NO)-mediated relaxation of colonic smooth muscle is crucial for the maintenance of human gut function. The… 
Highly Cited
2003
Highly Cited
2003
Association of phospholamban with a cGMP kinase signaling complex.
Highly Cited
2001
Highly Cited
2001
Molecular Determinants of the Interaction between the Inositol 1,4,5-Trisphosphate Receptor-associated cGMP Kinase Substrate (IRAG) and cGMP Kinase Iβ* 210
Cyclic GMP-dependent protein kinase I (cGKI) affects the inositol 1,4,5-trisphosphate (InsP3)-dependent release of intracellular… 
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