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MRC2 gene

Known as: endocytic receptor 180, UROKINASE-TYPE PLASMINOGEN ACTIVATOR RECEPTOR-ASSOCIATED PROTEIN, C-type lectin domain family 13 member E 
This gene is involved in extracellular matrix remodeling.
National Institutes of Health

Related topics

Related topics

5 relations
C-Type Mannose Receptor 2Extracellular Matrix DegradationLigand BindingReceptor Signaling

Narrower (1)

MRC2 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Role of urokinase plasminogen activator receptor-associated protein in mouse lung.
Urokinase plasminogen activator receptor-associated protein (uPARAP, or Endo180) is a transmembrane endocytic receptor that… Expand
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Highly Cited
2010
Highly Cited
2010
A Role for Fibrillar Collagen Deposition and the Collagen Internalization Receptor Endo180 in Glioma Invasion
Background Glioblastoma multiforme (GBM, WHO grade IV) is the most common and most malignant of astrocytic brain tumors, and is… Expand
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Highly Cited
2009
Highly Cited
2009
Balancing Selection of a Frame-Shift Mutation in the MRC2 Gene Accounts for the Outbreak of the Crooked Tail Syndrome in Belgian Blue Cattle
We herein describe the positional identification of a 2-bp deletion in the open reading frame of the MRC2 receptor causing the… Expand
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Highly Cited
2009
Highly Cited
2009
Membrane type-1 matrix metalloproteinase activity is regulated by the endocytic collagen receptor Endo180
The molecular interactions leading to organised, controlled extracellular matrix degradation are of central importance during… Expand
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Highly Cited
2007
Highly Cited
2007
Extracellular Collagenases and the Endocytic Receptor, Urokinase Plasminogen Activator Receptor-associated Protein/Endo180, Cooperate in Fibroblast-mediated Collagen Degradation*
The collagens of the extracellular matrix are the most abundant structural proteins in the mammalian body. In tissue remodeling… Expand
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Highly Cited
2006
Highly Cited
2006
Structural Model for the Mannose Receptor Family Uncovered by Electron Microscopy of Endo180 and the Mannose Receptor*
The mannose receptor family comprises four members in mammals, Endo180 (CD280), DEC-205 (CD205), phospholipase A2 receptor (PLA2R… Expand
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Highly Cited
2005
Highly Cited
2005
Intracellular collagen degradation mediated by uPARAP/Endo180 is a major pathway of extracellular matrix turnover during malignancy
We recently reported that uPARAP/Endo180 can mediate the cellular uptake and lysosomal degradation of collagen by cultured… Expand
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Highly Cited
2005
Highly Cited
2005
Gene expression profile of papillary thyroid cancer: sources of variability and diagnostic implications.
The study looked for an optimal set of genes differentiating between papillary thyroid cancer (PTC) and normal thyroid tissue and… Expand
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Highly Cited
2004
Highly Cited
2004
uPARAP/endo180 directs lysosomal delivery and degradation of collagen IV.
Collagen turnover is crucial for tissue homeostasis and remodeling and pathological processes such as cancer invasion, but the… Expand
Highly Cited
2002
Highly Cited
2002
J-Shaped Relationship between Blood Pressure and Mortality in Hypertensive Patients: New Insights from a Meta-Analysis of Individual-Patient Data
Context Lowering blood pressure in hypertensive patients decreases the risk for cardiovascular events. However, clinical trials… Expand
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