Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

MR 2266

Known as: MR-2266 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (2)

BenzomorphansNarcotic Antagonists

Narrower (2)

MR-2266-BSMr 2267

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1999
1999
The stereoselective κ-opioid receptor antagonist Mr 2266 does not exhibit stereoselectivity as an antagonist at the orphan opioid (ORL1) receptor
Mr 2266 [(-)-(1R,5R,9R)-5,9-diethyl-2-(3-furylmethyl)-2’-hydroxy-6,7-benzomorphan] is an antagonist at κ-opioid receptors and at… Expand
  • figure 1
  • table 1
  • figure 2
  • figure 3
1994
1994
Kappa-selective agonists decrease postsynaptic potentials and calcium components of action potentials in the supraoptic nucleus of rat hypothalamus in vitro
To investigate the effects of the endogenous kappa-receptor agonists dynorphin and leumorphin on neurons of the supraoptic… Expand
1991
1991
Effect of the kappa-receptor agonist, U-50,488H, on cerebral ischemia-induced impairment of working memory assessed in rats by a three-panel runway task.
The effect of U-50,488H, a selective kappa-receptor agonist, on memory functions in an animal model of cerebral ischemia was… Expand
Highly Cited
1989
Highly Cited
1989
Role of central opiate receptor subtypes in the circulatory responses of awake rabbits to graded caval occlusions.
1. In unanaesthetized rabbits, haemorrhage was simulated by inflating a cuff placed round the inferior vena cava so that cardiac… Expand
Highly Cited
1988
Highly Cited
1988
Influence of narcotic antagonist drugs upon nitrous oxide analgesia in mice
Nitrous oxide produced a concentration-related suppression of phenylquinone-induced abdominal constriction in mice. This… Expand
Highly Cited
1985
Highly Cited
1985
Spinal cord dynorphin may modulate nociception via a ℵ-opioid receptor in chronic arthritic rats
Abstract Inoculation of rats with Mycobacterium butyricum produced an arthritis of the limbs which revealed an enhanced… Expand
Highly Cited
1983
Highly Cited
1983
U-50,488: a selective and structurally novel non-Mu (kappa) opioid agonist.
U-50,488 (trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]-benzeneacetamide) displays analgesic actions in a variety… Expand
Highly Cited
1982
Highly Cited
1982
U-50,488, a selective kappa opioid agonist: Comparison to other reputed kappa agonists
1. U-50,488 is a structurally novel, non-mu opioid. In the present experiments it was compared to the reputed kappa opioid… Expand
Highly Cited
1982
Highly Cited
1982
Increased immunoreactive dynorphin and leu-enkephalin in posterior pituitary of obese mice (ob/ob) and super-sensitivity to drugs that act at kappa receptors.
Posterior pituitaries of obese mice (ob/ob) contained significantly more immunoreactive dynorphin (P less than .01) and leu… Expand
Highly Cited
1978
Highly Cited
1978
ENHANCEMENT OF A NOCICEPTIVE REACTION BY OPIOID ANTAGONISTS IN MICE
1 The opioid antagonists, naloxone, GPA 2163, levallorphan and Mr‐2266 reduced the latency of the jumping reaction of mice in the… Expand
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License
ACCEPT & CONTINUE