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Mr 2266 [(-)-(1R,5R,9R)-5,9-diethyl-2-(3-furylmethyl)-2’-hydroxy-6,7-benzomorphan] is an antagonist at κ-opioid receptors and at… Expand To investigate the effects of the endogenous kappa-receptor agonists dynorphin and leumorphin on neurons of the supraoptic… Expand The effect of U-50,488H, a selective kappa-receptor agonist, on memory functions in an animal model of cerebral ischemia was… Expand 1. In unanaesthetized rabbits, haemorrhage was simulated by inflating a cuff placed round the inferior vena cava so that cardiac… Expand Nitrous oxide produced a concentration-related suppression of phenylquinone-induced abdominal constriction in mice. This… Expand Abstract Inoculation of rats with Mycobacterium butyricum produced an arthritis of the limbs which revealed an enhanced… Expand U-50,488 (trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]-benzeneacetamide) displays analgesic actions in a variety… Expand 1. U-50,488 is a structurally novel, non-mu opioid. In the present experiments it was compared to the reputed kappa opioid… Expand Posterior pituitaries of obese mice (ob/ob) contained significantly more immunoreactive dynorphin (P less than .01) and leu… Expand 1 The opioid antagonists, naloxone, GPA 2163, levallorphan and Mr‐2266 reduced the latency of the jumping reaction of mice in the… Expand