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MM-401

 
National Institutes of Health

Papers overview

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2019
2019
TNFR2 is an emerging therapeutic target in immuno-oncology. We have previously shown that an agonistic mouse TNFR2 antibody was… Expand
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2019
2019
TNFR2 has been implicated as a novel target for cancer immunotherapy. While TNFR2 has been linked to enhanced suppressive… Expand
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2019
2019
TNFR2 is a member of the TNF receptor superfamily that is upregulated upon T cell activation and is highly expressed by tumor… Expand
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Review
2018
Review
2018
The histone H3 lysine 4 (H3K4) presenter WDR5 forms protein complexes with H3K4 methyltransferases MLL1-MLL4 and binding partner… Expand
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2018
2018
The transcription factor p53 plays an important role in suppression of tumor development, as it was involved in several important… Expand
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2017
2017
We report herein the design, synthesis, and evaluation of macrocyclic peptidomimetics that bind to WD repeat domain 5 (WDR5) and… Expand
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2017
2017
Pluripotent stem cells in the naïve state are highly useful in regenerative medicine and tissue engineering. A robust… Expand
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2016
2016
The interconversion between naive and primed pluripotent states is accompanied by drastic epigenetic rearrangements. However, it… Expand
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Review
2016
Review
2016
The rearrangements of the MLL located on the chromosome 11q23 are the major cause of mixed-lineage leukemia. The translocation… Expand
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Highly Cited
2014
Highly Cited
2014
Here we report a comprehensive characterization of our recently developed inhibitor MM-401 that targets the MLL1 H3K4… Expand
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