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MLL protein, human

Known as: KMT2A, Histone-Lysine N-Methyltransferase 2A, ALL-1 
Histone-lysine N-methyltransferase MLL (3969 aa, ~432 kDa) is encoded by the human MLL gene. This protein is involved in both histone modification… 
National Institutes of Health

Related topics

Related topics

15 relations
AT-Hook MotifsBromodomainDNA-Binding ProteinsEnzyme Gene

Broader (2)

Histone-Lysine N-MethyltransferaseMyeloid-Lymphoid Leukemia Protein

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
KMT2A and KMT2B Mediate Memory Function by Affecting Distinct Genomic Regions.
Highly Cited
2013
Highly Cited
2013
Histone-Methyltransferase MLL2 (KMT2B) Is Required for Memory Formation in Mice
The consolidation of long-term memories requires differential gene expression. Recent research has suggested that dynamic changes… 
Highly Cited
2011
Highly Cited
2011
Polycomb eviction as a new distant enhancer function.
Remote distal enhancers may be located tens or thousands of kilobases away from their promoters. How they control gene expression… 
Highly Cited
2010
Highly Cited
2010
A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription.
Highly Cited
2008
Highly Cited
2008
Integration of hepatitis B virus DNA into the myeloid/lymphoid or mixed‐lineage leukemia (MLL4) gene and rearrangements of MLL4 in human hepatocellular carcinoma
Integration of hepatitis B virus (HBV) DNA into host DNA is detected in about 90% of HBV‐related hepatocellular carcinoma (HCC… 
Highly Cited
2003
Highly Cited
2003
Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias.
Highly Cited
2001
Highly Cited
2001
Upregulation of Meis1 and HoxA9 in acute lymphocytic leukemias with the t(4 : 11) abnormality
Rearrangements of the human ALL-1 gene are frequently encountered in acute lymphocytic leukemias (ALL) and acute myeloid… 
Highly Cited
1997
Highly Cited
1997
Structure and expression pattern of human ALR, a novel gene with strong homology to ALL-1 involved in acute leukemia and to Drosophila trithorax
The ALL-1 gene is involved in human acute leukemia through chromosome translocations or internal rearrangements. ALL-1 is the… 
Highly Cited
1994
Highly Cited
1994
Molecular rearrangement of the ALL-1 gene in acute myeloid leukemia without cytogenetic evidence of 11q23 chromosomal translocations.
Translocations which involve chromosome band 11q23 are frequently found in infants and adults with acute myeloid leukemia (AML… 
Highly Cited
1994
Highly Cited
1994
ALL-1 partial duplication in acute leukemia.
The ALL-1 gene, located on chromosome band 11q23, is fused to a variety of other genes by reciprocal chromosomal translocations… 
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