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MLL/MLLT3 Fusion Gene

Known as: MLL-AF9 Fusion Gene, MLL-MLLT3 Fusion Gene, MLL/AF9 FUSION GENE 
A fusion gene that results from a chromosomal translocation t(9;11)(p22;q23) which fuses the 5' half of the MLL gene to the 3' end of the MLLT3 gene… 
National Institutes of Health

Related topics

Related topics

2 relations
KMT2A geneMLL/MLLT3 Fusion Protein

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2015
Review
2015
MLL Leukemia and Future Treatment Strategies
Chromosomal rearrangements of the MLL gene are associated with high‐risk infant, pediatric, adult, and therapy‐induced acute… 
Review
2015
Review
2015
Evidence-based RT-PCR methods for the detection of the 8 most common MLL aberrations in acute leukemias.
2014
2014
RNAi-mediated silencing of MLL-AF9 reveals leukemia-associated downstream targets and processes
BackgroundThe translocation t(9;11)(p22;q23) leading to the leukemogenic fusion gene MLL-AF9 is a frequent translocation in… 
Review
2013
Review
2013
Epigenetics and the control of the collecting duct epithelial sodium channel.
2012
2012
Secondary mutations in t(4;11) leukemia patients
MLL rearrangements are a genetic hallmark of acute leukemia patients, which exhibit a particular poor outcome. To date, more than… 
Highly Cited
2009
Highly Cited
2009
Bone marrow mesenchymal stem cells from infants with MLL-AF4+ acute leukemia harbor and express the MLL-AF4 fusion gene
MLL-AF4 fusion is a hallmark genetic abnormality in infant B-acute lymphoblastic leukemia (B-ALL) known to arise in utero. The… 
2006
2006
Imatinib mesylate does not impair the immunogenicity of human myeloid blood dendritic cells
Imatinib mesylate does not impair the immunogenicity of human myeloid blood dendritic cells 
Highly Cited
2005
Highly Cited
2005
Multiple Mixed Lineage Leukemia (MLL) Fusion Proteins Suppress p53-mediated Response to DNA Damage*
Chromosomal translocations involving the mixed lineage leukemia (MLL) gene are often observed in acute leukemias of both myeloid… 
2005
2005
Efficient and easy detection of MLL-AF4, MLL-AF9 and MLL-ENL fusion gene transcripts by multiplex real-time quantitative RT-PCR in TaqMan and LightCycler
Efficient and easy detection of MLL - AF4 , MLL - AF9 and MLL - ENL fusion gene transcripts by multiplex real-time quantitative… 
Highly Cited
2004
Highly Cited
2004
Hoxa9 influences the phenotype but not the incidence of Mll-AF9 fusion gene leukemia.
Identification of the targets of mixed lineage leukemia (MLL) fusion genes will assist in understanding the biology of MLL fusion… 
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