MLL/MLLT3 Fusion Gene

Known as: MLL-AF9 Fusion Gene, MLL-MLLT3 Fusion Gene, MLL/AF9 Fusion Gene 
A fusion gene that results from a chromosomal translocation t(9;11)(p22;q23) which fuses the 5' half of the MLL gene to the 3' end of the MLLT3 gene… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2005-2017
024620052017

Papers overview

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2014
2014
Mutant RAS oncoproteins activate signaling molecules that drive oncogenesis in multiple human tumors including acute myelogenous… (More)
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2012
2012
Although MLL-AF9 caused by the chromosomal translocation t(9;11) has a critical role in acute myeloid leukemia, the molecular… (More)
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2012
2012
Patients with a t(9;11) translocation (MLL-AF9) develop acute myeloid leukemia (AML), and while in mice the expression of this… (More)
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2011
2011
Ecotropic viral integration site-1 (Evi-1) is a nuclear transcription factor that plays an essential role in the regulation of… (More)
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Highly Cited
2011
Highly Cited
2011
Bmi1 is required for efficient self-renewal of hematopoietic stem cells (HSCs) and leukemic stem cells (LSCs). In this study, we… (More)
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Review
2010
Review
2010
One of the most common chromosomal breakpoint regions in acute myeloid leukaemia is the chromosome band 11q23. The analysis of… (More)
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Review
2009
Review
2009
In eukaryotic nuclei, genomic DNA is compacted with histone and nonhistone proteins into a dynamic polymer termed chromatin… (More)
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Highly Cited
2009
Highly Cited
2009
MLL-AF4 fusion is a hallmark genetic abnormality in infant B-acute lymphoblastic leukemia (B-ALL) known to arise in utero. The… (More)
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2007
2007
The aim of this study was to identify immunobiological subgroups in 133 infant acute lymphoblastic leukemia (ALL) cases as… (More)
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2005
2005
Chromosomal translocations involving the mixed lineage leukemia (MLL) gene are often observed in acute leukemias of both myeloid… (More)
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