MLH3 protein, human

Known as: mutL homolog 3 (E. coli) protein, human, mutL homolog 3 protein, human, MLH3 
DNA mismatch repair protein Mlh3 (1453 aa, ~164 kDa) is encoded by the human MLH3 gene. This protein is involved in DNA mismatch repair.
National Institutes of Health

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2008
2008
Interference-dependent crossing over in yeast and mammalian meioses involves the mismatch repair protein homologs MSH4-MSH5 and… (More)
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2005
2005
Germ line DNA mismatch repair mutations in MLH1 and MSH2 underlie the vast majority of hereditary non-polyposis colon cancer… (More)
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Highly Cited
2005
Highly Cited
2005
In humans, ~50% of conceptuses are chromosomally aneuploid as a consequence of errors in meiosis, and most of these aneuploid… (More)
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Highly Cited
2005
Highly Cited
2005
Mammalian MutL homologues function in DNA mismatch repair (MMR) after replication errors and in meiotic recombination. Both… (More)
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2003
2003
Mutations in the DNA MMR genes MSH2, MLH1, MSH6 and PMS2 underlie a large subset of HNPCC cases, and a hallmark of the tumors is… (More)
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Highly Cited
2001
Highly Cited
2001
We investigated a possible role of the mismatch-repair gene MLH3 in hereditary nonpolyposis colorectal cancer by scanning for… (More)
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Highly Cited
2000
Highly Cited
2000
DNA mismatch repair is important because of its role in maintaining genomic integrity and its association with hereditary non… (More)
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2000
2000
Microsatellite instability (MSI) is characteristic of hereditary nonpolyposis colorectal cancer, and occurs in a subset (10 to 15… (More)
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Highly Cited
1999
Highly Cited
1999
The yeast genome encodes four proteins (Pms1 and Mlh1-3) homologous to the bacterial mismatch repair component, MutL. Using two… (More)
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Highly Cited
1998
Highly Cited
1998
The Saccharomyces cerevisiae genome encodes four MutL homologs. Of these, MLH1 and PMS1 are known to act in the MSH2-dependent… (More)
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