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ML 00253764
Known as:
ML-00253764
, ML00253764
National Institutes of Health
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2020
Review
2020
Biased signaling in fish melanocortin-4 receptors (MC4Rs): Divergent pharmacology of four ligands on spotted scat (Scatophagus argus) and grass carp (Ctenopharyngodon idella) MC4Rs
Z. Yang
,
Xufang Liang
,
G. Li
,
Ya-Xiong Tao
Molecular and Cellular Endocrinology
2020
Corpus ID: 220253106
The melanocortin-4 receptor (MC4R) plays a critical role in the regulation of energy homeostasis in both mammals and fish…
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2018
2018
Melanocortin-4 receptor in swamp eel (Monopterus albus): Cloning, tissue distribution, and pharmacology.
Ti-Lin Yi
,
Li-Kun Yang
,
Guo-liang Ruan
,
Dai-qin Yang
,
Ya-Xiong Tao
Gene
2018
Corpus ID: 51912303
Melanocortin-4 receptor (MC4R) plays critical roles in the regulation of various physiological processes, such as energy…
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2017
2017
Melanocortin Receptor-4 and Glioblastoma Cells: Effects of the Selective Antagonist ML00253764 Alone and in Combination with Temozolomide In Vitro and In Vivo
F. Vaglini
,
C. Pardini
,
+7 authors
G. Bocci
Molecular Neurobiology
2017
Corpus ID: 3960783
Currently, no description of melanocortin receptor-4 (MC4R) expression or activity is available in human cancer cells, including…
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2014
2014
Rescue of defective MC4R cell-surface expression and signaling by a novel pharmacoperone Ipsen 17.
X. Wang
,
Hao-Meng Wang
,
B. Zhao
,
P. Yu
,
Z. Fan
Journal of molecular endocrinology
2014
Corpus ID: 23438422
Melanocortin 4 receptor (MC4R) is a key factor in regulating energy homeostasis, and null mutations occurring in the gene…
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2013
2013
Activation of MAPK by inverse agonists in six naturally occurring constitutively active mutant human melanocortin-4 receptors.
Xiu-Lei Mo
,
Ya-Xiong Tao
Biochimica et biophysica acta
2013
Corpus ID: 23080100
The melanocortin-4 receptor (MC4R) is a G protein-coupled receptor that plays an essential role in regulating energy homeostasis…
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2012
2012
Pleiotropic functions of the transmembrane domain 6 of human melanocortin-4 receptor.
H. Huang
,
Ya-Xiong Tao
Journal of molecular endocrinology
2012
Corpus ID: 46113254
The melanocortin-4 receptor (MC4R) is a critical regulator of energy homeostasis and has emerged as a premier target for obesity…
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Highly Cited
2009
Highly Cited
2009
Functional characterization and pharmacological rescue of melanocortin-4 receptor mutations identified from obese patients
Z. Fan
,
Ya-Xiong Tao
Journal of cellular and molecular medicine
2009
Corpus ID: 7911912
As the most common monogenic form of human obesity, about 130 naturally occurring melanocortin‐4 receptor (MC4R) gene mutations…
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Highly Cited
2006
Highly Cited
2006
Peripheral Administration of a Melanocortin 4-Receptor Inverse Agonist Prevents Loss of Lean Body Mass in Tumor-Bearing Mice
J. R. Nicholson
,
G. Kohler
,
F. Schaerer
,
C. Senn
,
P. Weyermann
,
K. Hofbauer
Journal of Pharmacology and Experimental…
2006
Corpus ID: 31740407
Cachexia affects many different chronically ill patient populations, including those with cancer. It results in loss of body…
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Highly Cited
2004
Highly Cited
2004
Identification of 2-[2-[2-(5-bromo-2- methoxyphenyl)-ethyl]-3-fluorophenyl]-4,5-dihydro-1H-imidazole (ML00253764), a small molecule melanocortin 4 receptor antagonist that effectively reduces tumor…
T. Vos
,
Andrei Caracoti
,
+15 authors
C. Claiborne
Journal of medicinal chemistry
2004
Corpus ID: 871099
The melanocortin 4 receptor (MC4R) plays an important role in body weight regulation and energy homeostasis. Administration of…
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