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ML 00253764

Known as: ML-00253764, ML00253764 
National Institutes of Health

Papers overview

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Review
2020
Review
2020
Biased signaling in fish melanocortin-4 receptors (MC4Rs): Divergent pharmacology of four ligands on spotted scat (Scatophagus argus) and grass carp (Ctenopharyngodon idella) MC4Rs
The melanocortin-4 receptor (MC4R) plays a critical role in the regulation of energy homeostasis in both mammals and fish… 
2018
2018
Melanocortin-4 receptor in swamp eel (Monopterus albus): Cloning, tissue distribution, and pharmacology.
Melanocortin-4 receptor (MC4R) plays critical roles in the regulation of various physiological processes, such as energy… 
2017
2017
Melanocortin Receptor-4 and Glioblastoma Cells: Effects of the Selective Antagonist ML00253764 Alone and in Combination with Temozolomide In Vitro and In Vivo
Currently, no description of melanocortin receptor-4 (MC4R) expression or activity is available in human cancer cells, including… 
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2014
2014
Rescue of defective MC4R cell-surface expression and signaling by a novel pharmacoperone Ipsen 17.
Melanocortin 4 receptor (MC4R) is a key factor in regulating energy homeostasis, and null mutations occurring in the gene… 
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2013
2013
Activation of MAPK by inverse agonists in six naturally occurring constitutively active mutant human melanocortin-4 receptors.
The melanocortin-4 receptor (MC4R) is a G protein-coupled receptor that plays an essential role in regulating energy homeostasis… 
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2012
2012
Pleiotropic functions of the transmembrane domain 6 of human melanocortin-4 receptor.
The melanocortin-4 receptor (MC4R) is a critical regulator of energy homeostasis and has emerged as a premier target for obesity… 
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Highly Cited
2009
Highly Cited
2009
Functional characterization and pharmacological rescue of melanocortin-4 receptor mutations identified from obese patients
As the most common monogenic form of human obesity, about 130 naturally occurring melanocortin‐4 receptor (MC4R) gene mutations… 
Highly Cited
2006
Highly Cited
2006
Peripheral Administration of a Melanocortin 4-Receptor Inverse Agonist Prevents Loss of Lean Body Mass in Tumor-Bearing Mice
Cachexia affects many different chronically ill patient populations, including those with cancer. It results in loss of body… 
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Highly Cited
2004
Highly Cited
2004
Identification of 2-[2-[2-(5-bromo-2- methoxyphenyl)-ethyl]-3-fluorophenyl]-4,5-dihydro-1H-imidazole (ML00253764), a small molecule melanocortin 4 receptor antagonist that effectively reduces tumor…
The melanocortin 4 receptor (MC4R) plays an important role in body weight regulation and energy homeostasis. Administration of… 
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