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MKNK1 protein, human

Known as: MAP Kinase Interacting Kinase 1, Mnk1, MAP Kinase-Interacting Serine/Threonine Kinase 1 
MAP kinase-interacting serine/threonine-protein kinase 1 (465 aa, ~51 kDa) is encoded by the human MKNK1 gene. This protein may play a role in… 
National Institutes of Health

Related topics

Related topics

21 relations
CDK10 protein, humanEnzyme GeneMAP Kinase-Interacting Serine/Threonine-Protein Kinase 2MAPKinase Signaling Pathway

Broader (1)

Protein-Serine-Threonine Kinases

Papers overview

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2018
2018
Abstract 5546: eFT508, a potent and highly selective inhibitor of MNK1 and MNK2, regulates T-cell differentiation promoting an antitumor immune response
An effective and durable T-cell response is a cornerstone of current immunotherapies. We show that eFT508, a potent, selective… 
2017
2017
Role of MNK1 in Buffalopox virus replication
2015
2015
Akt/mTOR/4E-BP1 and p38/Erk/Mnk1 signaling pathways regulates translation initiation factor 4E activation in the early stage of NDV infection
To determine the effect of Newcastle disease virus(NDV) infection on host translation machinery and associated signaling pathways… 
2013
2013
Mitogen-activated protein kinases activate the serine / threonine kinases Mnk 1 and Mnk 2 esters , Ca 2 and some G-protein-linked agonists activates
esters, Ca2 and some G-protein-linked agonists activates Andrew Jan Waskiewicz1,2, Andrea Flynn3, the Erk cascade. This cascade… 
2013
2013
The role of REM sleep in ocular dominance plasticity consolidation
Despite decades of research, the function of sleep remains controversial. One theory is that sleep plays a role in consolidating… 
2013
2013
Adenovirusspecific translation by displacement of kinase Mnk1 from capinitiation complex eIF4F
) ! /0 1 2 " " 3 " 4 & . * . " & ) ! " " ) ! . * % . ' 5. & 1 .+2 . !67& ) ! 1 .!2 55 " 1 .0-2 " " 10 * #8882* ! .0.0-" # 9 .0… 
2011
2011
Halogen- or cyano-substituted thieno [2,3-d] pyrimidines having Mnk1 / Mnk2 inhibitory activity for pharmaceutical compositions
The present invention can be influenced by inhibition of the kinase activity of novel thienopyrimidine compounds of general… 
2007
2007
Protein kinases as substrates for SAPKs
The stress-activated protein kinases (SAPKs) consist of the c-Jun N-terminal kinases (JNKs or SAPK1αβγ) and of the four p38 MAPK… 
2007
2007
Thienopyrimidine with Mnk1 / Mnk2 inhibitory activity of a pharmaceutical composition for
本発明は、チエノピリミジン化合物を含んで成る新規医薬組成物に関する。 さらに、本発明は、Ｍｎｋ１および／またはＭｎｋ２（Ｍｎｋ２ａまたはＭｎｋ２ｂ）および／またはそれらの変異体のキナーゼ活性の阻害に影響されうる疾患の予防および／または治療用の医薬組成物を製造するための、本発明のチエノピリミジン化合物の使用にも関する。 
2003
2003
Mnk1 Is Required for Angiotensin II–Induced Protein Synthesis in Vascular Smooth Muscle Cells
Angiotensin II (Ang II) stimulates protein synthesis in vascular smooth muscle cells (VSMCs), possibly secondary to regulatory…