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MK 912

Known as: MK-912 
 
National Institutes of Health

Papers overview

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2007
2007
BACKGROUND AND PURPOSE The reduction of skin blood flow induced by local cooling results from a reflex increase in sympathetic… Expand
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2004
2004
This study analyzed the regulation of alpha2-adrenoceptors (alpha2-ARs) in human vascular smooth muscle cells (VSMs). Saphenous… Expand
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Highly Cited
2002
Highly Cited
2002
1. Type 4 phosphodiesterase (PDE4) inhibitors mimic the pharmacological actions of alpha(2)-adrenoceptor antagonists. This has… Expand
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Review
2002
Review
2002
RX 821002 is the 2-methoxy congener of idazoxan. In binding and tissue studies it behaves as a selective antagonist of alpha(2… Expand
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Highly Cited
2001
Highly Cited
2001
The objective of this work was to assess the role of alpha(2)-adrenoceptors in emesis induced by inhibitors of type 4… Expand
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2001
2001
How and why the chemical stability of amorphous solid is different from crystalline solid is an important problem. In this study… Expand
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Highly Cited
2000
Highly Cited
2000
Cold constricts cutaneous blood vessels by increasing the reactivity of smooth muscle alpha(2)-adrenergic receptors (alpha(2)-ARs… Expand
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1998
1998
1. The mechanism underlying the anticataleptic properties of the atypical neuroleptic agent, clozapine, has been investigated in… Expand
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1998
1998
In vitro studies showed that MK-912 ((2S, 12bS)1',3'-dimethylspiro(1,3,4,5',6,6',7,12b-octahydro -2H-benzo[b]furo[2,3-a… Expand
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1991
1991
We used MK-912, a potent new selective alpha 2-adrenergic receptor antagonist that is active orally, to study the effect of short… Expand
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