MK 5108

Known as: MK-5108, MK5108 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2010-2017
02420102017

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Background MK-5108 is a potent/highly selective Aurora A kinase inhibitor. Methods A randomized Phase I study of MK-5108… (More)
  • table 1
  • table 2
  • table 3
  • table 4
  • figure 1
Is this relevant?
2015
2015
Mitosis is choreographed by a number of protein kinases including polo-like kinases and Aurora kinases. As these kinases are… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2015
2015
Aurora kinases are essential for cell division and are frequently misregulated in human cancers. Based on their potential as… (More)
Is this relevant?
2014
2014
Aurora kinases are key regulators of mitotic events. Dysfunction of these kinases can cause polyploidy and chromosomal… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2014
2014
Polo-like kinases (PLKs) and Aurora kinases (AKs) act as key cell cycle regulators in healthy human cells. In cancer, these… (More)
Is this relevant?
2014
2014
A number of small-molecule inhibitors of Aurora kinases have been developed and are undergoing clinical trials for anti-cancer… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2013
2013
The mechanism of the inhibitory effect of anti-GD2 ganglioside (GD2) 14G2a mouse monoclonal antibody (mAb) on human neuroblastoma… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2012
2012
PURPOSE Uterine leiomyosarcoma (ULMS) is a poorly understood cancer with few effective treatments. This study explores the… (More)
  • figure 1
  • table 1
  • table 1
  • figure 2
  • figure 3
Is this relevant?
2011
2011
Recurrent ovarian cancer is resistant to conventional chemotherapy. A sub-population of ovarian cancer cells, the epithelial… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2010
2010
Aurora-A kinase is a one of the key regulators during mitosis progression. Aurora-A kinase is a potential target for anticancer… (More)
  • figure 1
  • figure 2
  • figure 3
  • table 1
  • figure 4
Is this relevant?