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MK 5108

Known as: MK-5108, MK5108 
National Institutes of Health

Papers overview

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2015
2015
SummaryBackground MK-5108 is a potent/highly selective Aurora A kinase inhibitor. Methods A randomized Phase I study of MK-5108… 
Highly Cited
2015
Highly Cited
2015
Aurora kinases are essential for cell division and are frequently misregulated in human cancers. Based on their potential as… 
2014
2014
AbstractPurpose Aurora kinases are key regulators of mitotic events. Dysfunction of these kinases can cause polyploidy and… 
Highly Cited
2014
Highly Cited
2014
A number of small-molecule inhibitors of Aurora kinases have been developed and are undergoing clinical trials for anti-cancer… 
Highly Cited
2012
Highly Cited
2012
Purpose: Uterine leiomyosarcoma (ULMS) is a poorly understood cancer with few effective treatments. This study explores the… 
Highly Cited
2011
Highly Cited
2011
Recurrent ovarian cancer is resistant to conventional chemotherapy. A sub-population of ovarian cancer cells, the epithelial… 
Highly Cited
2011
Highly Cited
2011
MK-0457 and MK-5108 are novel aurora kinase inhibitors (AKi) leading to G(2)-M cell-cycle arrest. Growth and survival of multiple… 
Highly Cited
2010
Highly Cited
2010
Aurora-A kinase is a one of the key regulators during mitosis progression. Aurora-A kinase is a potential target for anticancer… 
2010
2010
e13026 Background: MK-5108 is a potent, highly selective Aurora A kinase inhibitor. Aurora A is a serine/threonine kinase that…