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Aurora kinases are essential for cell division and are frequently misregulated in human cancers. Based on their potential as… Expand SummaryBackground MK-5108 is a potent/highly selective Aurora A kinase inhibitor. Methods A randomized Phase I study of MK-5108… Expand AbstractPurpose
Aurora kinases are key regulators of mitotic events. Dysfunction of these kinases can cause polyploidy and… Expand A number of small-molecule inhibitors of Aurora kinases have been developed and are undergoing clinical trials for anti-cancer… Expand The mechanism of the inhibitory effect of anti-GD2 ganglioside (GD2) 14G2a mouse monoclonal antibody (mAb) on human neuroblastoma… Expand Purpose: Uterine leiomyosarcoma (ULMS) is a poorly understood cancer with few effective treatments. This study explores the… Expand Recurrent ovarian cancer is resistant to conventional chemotherapy. A sub-population of ovarian cancer cells, the epithelial… Expand MK-0457 and MK-5108 are novel aurora kinase inhibitors (AKi) leading to G(2)-M cell-cycle arrest. Growth and survival of multiple… Expand Aurora-A kinase is a one of the key regulators during mitosis progression. Aurora-A kinase is a potential target for anticancer… Expand e13026 Background: MK-5108 is a potent, highly selective Aurora A kinase inhibitor. Aurora A is a serine/threonine kinase that… Expand