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MK 499
Known as:
MK-499
National Institutes of Health
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Related topics
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1 relation
L 706000
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
New insights about HERG blockade obtained from protein modeling, potential energy mapping, and docking studies.
R. Farid
,
T. Day
,
R. Friesner
,
R. Pearlstein
Bioorganic & medicinal chemistry
2006
Corpus ID: 18090070
Highly Cited
2006
Highly Cited
2006
Molecular Determinants of hERG Channel Block
K. Kamiya
,
R. Niwa
,
J. Mitcheson
,
M. Sanguinetti
Molecular Pharmacology
2006
Corpus ID: 30911146
Drug-induced block of cardiac hERG K+ channels causes acquired long QT syndrome. Here, we characterized the molecular mechanism…
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Highly Cited
2004
Highly Cited
2004
Physicochemical Features of the hERG Channel Drug Binding Site*
David Fernandez
,
Azad Ghanta
,
Gregory W. Kauffman
,
M. Sanguinetti
Journal of Biological Chemistry
2004
Corpus ID: 19887014
Blockade of hERG K+ channels in the heart is an unintentional side effect of many drugs and can induce cardiac arrhythmia and…
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Highly Cited
2001
Highly Cited
2001
Open channel block of HERG K(+) channels by vesnarinone.
K. Kamiya
,
J. Mitcheson
,
K. Yasui
,
I. Kodama
,
M. Sanguinetti
Molecular pharmacology
2001
Corpus ID: 33175449
Vesnarinone, a cardiotonic agent, blocks I(Kr) and, unlike other I(Kr) blockers, produces a frequency-dependent prolongation of…
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Highly Cited
2000
Highly Cited
2000
A structural basis for drug-induced long QT syndrome.
J. Mitcheson
,
J. Chen
,
M. Lin
,
C. Culberson
,
M. Sanguinetti
Proceedings of the National Academy of Sciences…
2000
Corpus ID: 41765968
Highly Cited
2000
Highly Cited
2000
Trapping of a Methanesulfonanilide by Closure of the Herg Potassium Channel Activation Gate
J. Mitcheson
,
Jun Chen
,
M. Sanguinetti
The Journal of general physiology
2000
Corpus ID: 10661161
Deactivation of voltage-gated potassium (K+) channels can slow or prevent the recovery from block by charged organic compounds, a…
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Highly Cited
1998
Highly Cited
1998
A novel benzodiazepine that activates cardiac slow delayed rectifier K+ currents.
J. Salata
,
N. Jurkiewicz
,
J. Wang
,
B. Evans
,
H. T. Orme
,
M. Sanguinetti
Molecular pharmacology
1998
Corpus ID: 19579218
The slowly activating delayed rectifier K+ current, IKs, is an important modulator of cardiac action potential repolarization…
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Highly Cited
1998
Highly Cited
1998
Molecular determinants of dofetilide block of HERG K+ channels.
E. Ficker
,
W. Jarolimek
,
J. Kiehn
,
A. Baumann
,
A. Brown
Circulation research
1998
Corpus ID: 7210342
The human ether-a-go-go-related gene (HERG) encodes a K+ channel with biophysical properties nearly identical to the rapid…
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Highly Cited
1996
Highly Cited
1996
Class III antiarrhythmic drugs block HERG, a human cardiac delayed rectifier K+ channel. Open-channel block by methanesulfonanilides.
P. Spector
,
M. Curran
,
M. Keating
,
M. Sanguinetti
Circulation research
1996
Corpus ID: 10092967
We recently reported that mutations in HERG, a potassium channel gene, cause long QT syndrome. Heterologous expression of HERG in…
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Highly Cited
1994
Highly Cited
1994
Cardiac electrophysiologic and antiarrhythmic actions of two long-acting spirobenzopyran piperidine class III agents, L-702,958 and L-706,000 [MK-499].
J. Lynch
,
A. Wallace
,
+7 authors
R. Stein
The Journal of pharmacology and experimental…
1994
Corpus ID: 29587479
The cardiac electrophysiologic and antiarrhythmic actions of two Class III ketone- and alcohol-containing spirobenzopyran…
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