Skip to search formSkip to main contentSkip to account menu

MK 499

Known as: MK-499 
National Institutes of Health

Related topics

Related topics

1 relation
L 706000

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
New insights about HERG blockade obtained from protein modeling, potential energy mapping, and docking studies.
Highly Cited
2006
Highly Cited
2006
Molecular Determinants of hERG Channel Block
Drug-induced block of cardiac hERG K+ channels causes acquired long QT syndrome. Here, we characterized the molecular mechanism… 
Highly Cited
2004
Highly Cited
2004
Physicochemical Features of the hERG Channel Drug Binding Site*
Blockade of hERG K+ channels in the heart is an unintentional side effect of many drugs and can induce cardiac arrhythmia and… 
Highly Cited
2001
Highly Cited
2001
Open channel block of HERG K(+) channels by vesnarinone.
Vesnarinone, a cardiotonic agent, blocks I(Kr) and, unlike other I(Kr) blockers, produces a frequency-dependent prolongation of… 
Highly Cited
2000
Highly Cited
2000
A structural basis for drug-induced long QT syndrome.
Highly Cited
2000
Highly Cited
2000
Trapping of a Methanesulfonanilide by Closure of the Herg Potassium Channel Activation Gate
Deactivation of voltage-gated potassium (K+) channels can slow or prevent the recovery from block by charged organic compounds, a… 
Highly Cited
1998
Highly Cited
1998
A novel benzodiazepine that activates cardiac slow delayed rectifier K+ currents.
The slowly activating delayed rectifier K+ current, IKs, is an important modulator of cardiac action potential repolarization… 
Highly Cited
1998
Highly Cited
1998
Molecular determinants of dofetilide block of HERG K+ channels.
The human ether-a-go-go-related gene (HERG) encodes a K+ channel with biophysical properties nearly identical to the rapid… 
Highly Cited
1996
Highly Cited
1996
Class III antiarrhythmic drugs block HERG, a human cardiac delayed rectifier K+ channel. Open-channel block by methanesulfonanilides.
We recently reported that mutations in HERG, a potassium channel gene, cause long QT syndrome. Heterologous expression of HERG in… 
Highly Cited
1994
Highly Cited
1994
Cardiac electrophysiologic and antiarrhythmic actions of two long-acting spirobenzopyran piperidine class III agents, L-702,958 and L-706,000 [MK-499].
The cardiac electrophysiologic and antiarrhythmic actions of two Class III ketone- and alcohol-containing spirobenzopyran… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License