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MK 499

Known as: MK-499 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1994-2015
012319942015

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1 relation
L 706000

Related mentions per year

Related mentions per year

1994-2015
1990200020102020
MK 499
L 706000

Papers overview

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2007
2007
A highly sensitive canine telemetry model for detection of QT interval prolongation: studies with moxifloxacin, haloperidol and MK-499.
INTRODUCTION Preclinical evaluation of delayed ventricular repolarization manifests electrocardiographically as QT interval… (More)
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2006
2006
Molecular determinants of HERG channel block.
Drug-induced block of cardiac hERG K+ channels causes acquired long QT syndrome. Here, we characterized the molecular mechanism… (More)
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Highly Cited
2004
Highly Cited
2004
Physicochemical features of the HERG channel drug binding site.
Blockade of hERG K(+) channels in the heart is an unintentional side effect of many drugs and can induce cardiac arrhythmia and… (More)
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Highly Cited
2000
Highly Cited
2000
A structural basis for drug-induced long QT syndrome.
Mutations in the HERG K(+) channel gene cause inherited long QT syndrome (LQT), a disorder of cardiac repolarization that… (More)
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Highly Cited
2000
Highly Cited
2000
Trapping of a Methanesulfonanilide by Closure of the Herg Potassium Channel Activation Gate
Deactivation of voltage-gated potassium (K(+)) channels can slow or prevent the recovery from block by charged organic compounds… (More)
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Highly Cited
1998
Highly Cited
1998
Molecular determinants of dofetilide block of HERG K+ channels.
The human ether-a-go-go-related gene (HERG) encodes a K+ channel with biophysical properties nearly identical to the rapid… (More)
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1998
1998
Metabolism of MK-499, a class III antiarrhythmic agent, in rats and dogs.
MK-499 [(+)-N-[1'-(6-cyano-1, 2, 3, 4-tetrahydro-2(R)-naphthalenyl)-3, 4-dihydro-4(R)-hydroxyspiro(2H-1-benzopyran-2, 4… (More)
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1997
1997
Single HERG delayed rectifier K+ channels expressed in Xenopus oocytes.
HERG is a K+ channel with properties similar to the rapidly activating component (I(Kr)) of delayed rectifier K+ current, which… (More)
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Highly Cited
1996
Highly Cited
1996
Class III antiarrhythmic drugs block HERG, a human cardiac delayed rectifier K+ channel. Open-channel block by methanesulfonanilides.
We recently reported that mutations in HERG, a potassium channel gene, cause long QT syndrome. Heterologous expression of HERG in… (More)
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1994
1994
Cardiac electrophysiologic and antiarrhythmic actions of two long-acting spirobenzopyran piperidine class III agents, L-702,958 and L-706,000 [MK-499].
The cardiac electrophysiologic and antiarrhythmic actions of two Class III ketone- and alcohol-containing spirobenzopyran… (More)
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