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MK 458

Known as: 2H-Naphth(1,2-b)-1,4-oxazin-9-ol, 3,4,4a,5,6,10b-hexahydro-4-propyl-, hydrochloride, (4aR-trans)-, MK-458 
 
National Institutes of Health

Papers overview

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1993
1993
To the Editor. —We were pleased to read the article entitled "Dopamine Agonist Treatment of Fluctuating Parkinsonism," 1 which… Expand
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1992
1992
Adjunctive treatment with the very potent and selective dopamine D-2 agonist MK-458 (controlled-release formulation) improved the… Expand
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1992
1992
SummaryTo investigate the pharmacokinetic profile, bioavailability, and dose proportionality of the D2-agonist MK-458… Expand
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1991
1991
The potent and selective dopamine D-2 agonist, MK-458 [PHNO; (+)-4-propyl-9-hydroxynaphthoxazine] was administered as monotherapy… Expand
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1991
1991
Ninety-four patients with early Parkinson's disease were investigated in a double-blind, placebo-controlled evaluation of MK-458… Expand
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1990
1990
4-Propyl-9-hydroxynaphthoxazine, or MK-458 (HPMC), a selective, nonergot D2 agonist administered orally twice a day in sustained… Expand
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1988
1988
MK 458 is a potent and selective D2 receptor agonist. MK 458 consists of (+)-4-propyl-9-hydroxynaphthoxazine (PHNO) in a… Expand
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