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MK-3118

 
National Institutes of Health

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2017
2017
ABSTRACT SCY-078 (MK-3118) is a novel, semisynthetic derivative of enfumafungin and represents the first compound of the… Expand
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2017
2017
SCY-078 (formerly MK-3118) is a novel orally active inhibitor of fungal β-(1,3)-glucan synthase (GS). SCY-078 is a derivative of… Expand
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2015
2015
The limited armamentarium of active and oral antifungal drugs against emerging non-Aspergillus molds is of particular concern… Expand
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2015
2015
Echinocandins inhibit the synthesis of β-1,3-D-glucan in Candida and are the first-line therapy in numerous clinical settings… Expand
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Highly Cited
2014
Highly Cited
2014
MK-3118 is as an orally active new antifungal in the early stage of clinical development that inhibits the biosynthesis of β-(1,3… Expand
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2013
2013
OBJECTIVES To evaluate the activity of the orally bioavailable enfumafungin derivative MK-3118 and comparator antifungal agents… Expand
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2013
2013
MK-3118, a glucan synthase inhibitor derived from enfumafungin, and comparator agents were tested against 71 Aspergillus spp… Expand
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2012
2012
• MK-3118 is a potent, novel antifungal agent with impressive activity against both WT and antifungal-resistant strains of… Expand
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Review
2011
Review
2011
Introduction: New classes of synthetic and semi-synthetic β-glucan inhibitors have recently emerged, providing analogs that, in… Expand
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2010
2010
  • Karen Walker
  • IDrugs : the investigational drugs journal
  • 2010
  • Corpus ID: 28249953
The 50th annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), held in Boston, included topics… Expand
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