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MK 0518

Known as: 0518, MK, MK-0518, MK0518 
National Institutes of Health

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2 relations

Broader (2)

raltegravirraltegravir potassium

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2011
Review
2011
HIV-1 Integrase Inhibitors: A Review of Their Chemical Development
Highly active antiretroviral therapy (HAART) significantly decreases plasma viral load, increases CD4+ T-cell counts in HIV-1… 
2010
2010
Reforming country health systems for women's health
2009
2009
The G 140 S mutation in HIV integrases from raltegravir-resistant patients rescues catalytic defect due to the resistance Q 148 H mutation
Raltegravir (MK-0518) is the first integrase (IN) inhibitor to be approved by the US FDA and is currently used in clinical… 
2009
2009
New hexahydrodiazocino-naphthyridine triones as HIV-1 integrase inhibitors: WO2008048538 A1
Since the discovery of MK-0518 (raltegravir, the first FDA-approved integrase inhibitor) in October 2007, Merck Co. researchers… 
2009
2009
Two Receptor Based Pharmacophore Models for HIV-1 Integrase DKA Inhibitors
Hiv-1 integrase (IN) is an important and validated target for drug design. The diketo acid (DKA) compounds were identified as… 
Review
2008
Review
2008
Anti-infectives: clinical progress of HIV-1 integrase inhibitors.
BACKGROUND HIV-1 integrase (IN) represents a therapeutically advantageous viral target to treat HIV/AIDS in the clinic. Over a… 
2007
2007
Studies of metabolism and disposition of potent human immunodeficiency virus (HIV) integrase inhibitors using 19F-NMR spectroscopy
19F-nuclear magnetic resonance (NMR) has been extensively used in a drug-discovery programme to support the selection of… 
2007
2007
Expanded access drug profile: raltegravir (RAL, MK-0518).
2006
2006
Integrase inhibitor MK-0518: Merck opens expanded-access program.
Patients resistant to at least one drug in all three oral classes may qualify for this new kind of antiretroviral--which still… 
2006
2006
Inhibitors of human immunodeficiency virus type I
The virally encoded enzyme integrase plays a critical role in HIV-1 replication and has long been considered a promising target… 
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