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MEIS1 protein, human

Known as: MEIS1 Homeobox Protein, Homeobox Protein Meis1, MEIS1 Homolog 
MEIS1 Homeobox Protein Homeobox protein Meis1 (390 aa, ~43 kDa) is encoded by the human MEIS1 gene. This protein plays a role in transcriptional… 
National Institutes of Health

Related topics

Related topics

11 relations
Cell NucleusCerebellumDNA-Binding ProteinsFetal Liver

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
DNA-dependent formation of transcription factor pairs alters their binding specificity
Gene expression is regulated by transcription factors (TFs), proteins that recognize short DNA sequence motifs. Such sequences… 
Highly Cited
2009
Highly Cited
2009
HOXA9 is required for survival in human MLL-rearranged acute leukemias.
Leukemias that harbor translocations involving the mixed lineage leukemia gene (MLL) possess unique biologic characteristics and… 
Highly Cited
2008
Highly Cited
2008
Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin
Acute myeloid leukemia (AML) carrying NPM1 mutations and cytoplasmic nucleophosmin (NPMc+ AML) accounts for about one-third of… 
Highly Cited
2007
Highly Cited
2007
Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential.
Oncogenic mutations of the MLL histone methyltransferase confer an unusual ability to transform non-self-renewing myeloid… 
Highly Cited
2006
Highly Cited
2006
Multiple imprinted and stemness genes provide a link between normal and tumor progenitor cells of the developing human kidney.
Wilms' tumor (WT), the embryonic kidney malignancy, is suggested to evolve from a progenitor cell population of uninduced… 
Highly Cited
2005
Highly Cited
2005
The homeodomain protein Meis1 is essential for definitive hematopoiesis and vascular patterning in the mouse embryo.
Highly Cited
2004
Highly Cited
2004
Hematopoietic, angiogenic and eye defects in Meis1 mutant animals
Meis1 and Hoxa9 expression is upregulated by retroviral integration in murine myeloid leukemias and in human leukemias carrying… 
Highly Cited
2002
Highly Cited
2002
Meis homeoproteins directly regulate Pax6 during vertebrate lens morphogenesis.
Pax6 is a pivotal regulator of eye development throughout Metazoa, but the direct upstream regulators of vertebrate Pax6… 
Review
1999
Review
1999
Frequent co-expression of the HOXA9 and MEIS1 homeobox genes in human myeloid leukemias
There is increasing evidence that HOX homeobox genes play a role in leukemogenesis. Recent studies have demonstrated that… 
Highly Cited
1995
Highly Cited
1995
Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice
Leukemia results from the accumulation of multiple genetic alterations that disrupt the control mechanisms of normal growth and… 
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