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MEHD7945A

Known as: MEHD 7945A, MEHD-7945A 
 
National Institutes of Health

Papers overview

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2017
2017
2568 Background: Dysregulated human epidermal growth factor receptor tyrosine kinase (HER RTK) signaling is an important driver… Expand
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2016
2016
BACKGROUND Duligotuzumab, a novel dual-action humanized IgG1 antibody that blocks ligand binding to epidermal growth factor… Expand
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2016
2016
BACKGROUND This open-label, multicenter, phase Ib study assessed the safety and preliminary activity of duligotuzumab, a dual… Expand
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2015
2015
PURPOSE The novel dual-action humanized IgG1 antibody MEHD7945A targeting HER3 and EGFR inhibits ligand-dependent HER dimer… Expand
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2015
2015
Human epidermal growth factor receptor family members (EGFR, HER2, HER3, and HER4) play important roles in tumorigenesis and… Expand
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Highly Cited
2014
Highly Cited
2014
Both abundant epidermal growth factor receptor (EGFR or ErbB1) and high activity of the phosphatidylinositol 3-kinase (PI3K)–Akt… Expand
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Review
2014
Review
2014
Overexpression of the epidermal growth factor receptor (EGFR) is a common characteristic of head and neck squamous cell… Expand
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Highly Cited
2013
Highly Cited
2013
EGF receptor (EGFR) inhibition is efficacious in cancer therapy, but initially sensitive tumors often develop resistance. In this… Expand
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Highly Cited
2011
Highly Cited
2011
Extensive crosstalk among ErbB/HER receptors suggests that blocking signaling from more than one family member may be essential… Expand
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2011
2011
PurposeMEHD7945A is a novel dual-action monoclonal antibody in which each of the two antigen-binding fragments is capable of… Expand
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