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MEDI 493
Known as:
Monoclonal Antibody MEDI-493
, MEDI-493, Monoclonal Antibody
, MEDI-493
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National Institutes of Health
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Related topics
Related topics
1 relation
Broader (1)
palivizumab
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Identification of a single tryptophan residue as critical for binding activity in a humanized monoclonal antibody against respiratory syncytial virus.
Ziping Wei
,
Jinhua Feng
,
+7 authors
M. Schenerman
Analytical Chemistry
2007
Corpus ID: 25542706
We have identified a single tryptophan (Trp) residue responsible for loss of binding and biological activity upon ultraviolet (UV…
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Review
2000
Review
2000
Respiratory syncytial virus prevention: past and present strategies
A. Greenough
,
M. Thomas
Expert Opinion on Pharmacotherapy
2000
Corpus ID: 26387815
Respiratory syncytial virus (RSV) is a common cause of respiratory illness in young children, almost all will have been infected…
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Highly Cited
1999
Highly Cited
1999
A direct comparison of the activities of two humanized respiratory syncytial virus monoclonal antibodies: MEDI-493 and RSHZl9.
S. Johnson
,
S. Griego
,
+7 authors
S. Dillon
Journal of Infectious Diseases
1999
Corpus ID: 32926772
Two humanized monoclonal antibodies, MEDI-493 and RSHZ19, were developed independently as potential improvements over RSV-IGIV…
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Highly Cited
1998
Highly Cited
1998
Safety, tolerance and pharmacokinetics of a humanized monoclonal antibody to respiratory syncytial virus in premature infants and infants with bronchopulmonary dysplasia. MEDI-493 Study Group.
K. N. Subramanian
,
L. Weisman
,
+8 authors
E. Connor
The Pediatric Infectious Disease Journal
1998
Corpus ID: 22274099
BACKGROUND Respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract infection in infants. MEDI-493…
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Highly Cited
1998
Highly Cited
1998
Reduction of respiratory syncytial virus (RSV) in tracheal aspirates in intubated infants by use of humanized monoclonal antibody to RSV F protein.
R. Malley
,
J. Devincenzo
,
+10 authors
D. Ambrosino
Journal of Infectious Diseases
1998
Corpus ID: 21164610
Thirty-five children <2 years of age mechanically ventilated for respiratory syncytial virus (RSV) infection were randomized to…
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1998
1998
Safety and pharmacokinetics of an intramuscular humanized monoclonal antibody to respiratory syncytial virus in premature infants and infants with bronchopulmonary dysplasia. The MEDI-493 Study Group…
X. Sáez-Llorens
,
E. Castaño
,
+5 authors
E. Connor
The Pediatric Infectious Disease Journal
1998
Corpus ID: 24361512
BACKGROUND Respiratory syncytial virus (RSV) is the leading cause of lower respiratory disease in infants and children. MEDI-493…
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Highly Cited
1998
Highly Cited
1998
Safety and pharmacokinetics of an intramuscular humanized monoclonal antibody to respiratory syncytial virus in premature infants and infants with bronchopulmonary dysplasia
X. Sáez-Llorens
,
E. Castaño
,
+5 authors
E. Connor
1998
Corpus ID: 71920687
Background.Respiratory syncytial virus (RSV) is the leading cause of lower respiratory disease in infants and children. MEDI-493…
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1998
1998
Phase I/II, Double-blind, Placebo-controlled, Multi-dose Escalation Trial of a Humanized Respiratory Syncytial Virus (RSV) Monoclonal Antibody (MEDI-493) in Children Hospitalized with RSV • 906
X. Sáez-Llorens
,
M. Moreno
,
O. Ramilo
,
P. Sánchez
,
E. Connor
Pediatric Research
1998
Corpus ID: 35902374
MEDI-493, a humanized monoclonal antibody to the F-protein of RSV, is highly active against RSV. The objective of this study was…
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Highly Cited
1997
Highly Cited
1997
Development of a humanized monoclonal antibody (MEDI-493) with potent in vitro and in vivo activity against respiratory syncytial virus.
S. Johnson
,
C. Oliver
,
+13 authors
J. F. Young
Journal of Infectious Diseases
1997
Corpus ID: 45101783
Neutralizing polyclonal antibody to respiratory syncytial virus (RSV) has been shown to be an effective prophylactic agent when…
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1997
1997
RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, DOSE-ESCALATION TRIAL OF A HUMANIZED RESPIRATORY SYNCYTIAL VIRUS (RSV) MONOCLONAL ANTIBODY (MEDI-493) IN HIGH RISK INFANTS. • 768
K. N. Subramanian
,
L. Weisman
,
T. Rhodes
,
E. Connor
Pediatric Research
1997
Corpus ID: 5972920
AIM: MEDI-493 is directed against the F protein of RSVand is broadly reactive against RSV in vitro. Serum levels of 25-30 ug/ml…
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