MEDI 493

We have identified a single tryptophan (Trp) residue responsible for loss of binding and biological activity upon ultraviolet (UV… Expand

Respiratory syncytial virus (RSV) is a common cause of respiratory illness in young children, almost all will have been infected… Expand

Two humanized monoclonal antibodies, MEDI-493 and RSHZ19, were developed independently as potential improvements over RSV-IGIV… Expand

BACKGROUND Respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract infection in infants. MEDI-493… Expand

Thirty-five children <2 years of age mechanically ventilated for respiratory syncytial virus (RSV) infection were randomized to… Expand

BACKGROUND Respiratory syncytial virus (RSV) is the leading cause of lower respiratory disease in infants and children. MEDI-493… Expand

Background.Respiratory syncytial virus (RSV) is the leading cause of lower respiratory disease in infants and children. MEDI-493… Expand

MEDI-493, a humanized monoclonal antibody to the F-protein of RSV, is highly active against RSV. The objective of this study was… Expand

Neutralizing polyclonal antibody to respiratory syncytial virus (RSV) has been shown to be an effective prophylactic agent when… Expand

AIM: MEDI-493 is directed against the F protein of RSVand is broadly reactive against RSV in vitro. Serum levels of 25-30 ug/ml… Expand