MED12 gene

Known as: CAGH45, TRAP230, TRINUCLEOTIDE REPEAT-CONTAINING GENE 11 
This gene plays a role in the regulation of RNA polymerase II-dependent transcription.
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
The simplicity of programming the CRISPR (clustered regularly interspaced short palindromic repeats)–associated nuclease Cas9 to… (More)
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Highly Cited
2012
Highly Cited
2012
Prostate cancer is the second most common cancer in men worldwide and causes over 250,000 deaths each year. Overtreatment of… (More)
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Highly Cited
2012
Highly Cited
2012
Inhibitors of the ALK and EGF receptor tyrosine kinases provoke dramatic but short-lived responses in lung cancers harboring EML4… (More)
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Highly Cited
2012
Highly Cited
2012
Recurrent somatic mutations in MED12 exon 2 have recently been reported in uterine leiomyomas. The recurrent nature of the… (More)
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Highly Cited
2011
Highly Cited
2011
Uterine leiomyomas, or fibroids, are benign tumors that affect millions of women worldwide and that can cause considerable… (More)
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Highly Cited
2007
Highly Cited
2007
A novel missense mutation in the mediator of RNA polymerase II transcription subunit 12 (MED12) gene has been found in the… (More)
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Highly Cited
2006
Highly Cited
2006
The dynamin-like GTPase OPA1, a causal gene product of human dominant optic atrophy, functions in mitochondrial fusion and inner… (More)
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Highly Cited
2006
Highly Cited
2006
Rhomboids, evolutionarily conserved integral membrane proteases, participate in crucial signaling pathways. Presenilin-associated… (More)
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Highly Cited
2004
Highly Cited
2004
The regulated equilibrium between mitochondrial fusion and fission is essential to maintain integrity of the organelle… (More)
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Highly Cited
2004
Highly Cited
2004
During apoptosis, the mitochondrial network fragments. Using short hairpin RNAs for RNA interference, we manipulated the… (More)
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