MDM2 SNP309 Allele

Known as: MDM2 c.14+309T>G, MDM2 c.309T>G, NC_000012.11:g.75896664C>T 
A single nucleotide polymorphism in the MDM2 gene associated with an earlier onset of tumors in both sporadic and hereditary cancers.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1994-2017
010203019942017

Papers overview

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Highly Cited
2010
Highly Cited
2010
In chronic lymphocytic leukemia (B-CLL), aberrations along the p53 axis lead to decreased overall survival and therapy resistance… (More)
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2009
2009
MDM2 SNP309 is a single nucleotide T > G polymorphism present in intron 1 of the MDM2 gene. A variety of case–control studies… (More)
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2008
2008
The p53 tumor suppressor directs the cellular response to many mechanistically distinct DNA-damaging agents and is selected… (More)
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Highly Cited
2007
Highly Cited
2007
A paper by Bond et al. reported that a single-nucleotide polymorphism (SNP) in the intronic promoter region of the mouse double… (More)
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Highly Cited
2006
Highly Cited
2006
The importance of the p53 stress response pathway in the suppression of tumor formation is well documented. In a previous report… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND A common single-nucleotide polymorphism (SNP) in the promoter region of the MDM2 gene, known as T-309G and referred to… (More)
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Highly Cited
2006
Highly Cited
2006
Recent studies have shown that the G-allele of MDM2 SNP309 (T/G) in the p53 tumour suppressor pathway can accelerate… (More)
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Highly Cited
2005
Highly Cited
2005
In cancer cells, the function of the tumor suppressor protein p53 is usually blocked. Impairment of the p53 pathway results in… (More)
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Highly Cited
2005
Highly Cited
2005
PURPOSE The Arg/Pro polymorphism in codon 72 of p53 was recently associated with age of onset of colorectal cancer in Lynch… (More)
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Highly Cited
2004
Highly Cited
2004
The tumor suppressor p53 gene is mutated in minimally half of all cancers. It is therefore reasonable to assume that naturally… (More)
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