MDCO-216
National Institutes of Health
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The risk of heart failure (HF) is prominently increased in patients with type 2 diabetes mellitus. The objectives of this study…
Importance Infusing a high-density lipoprotein mimetic containing apolipoprotein A-I Milano demonstrated potential atheroma…
The pleiotropic properties of HDL may exert beneficial effects on the myocardium. The effect of recombinant HDLMilano on…
Heart failure with preserved ejection fraction (HFpEF) represents a major unmet therapeutic need. This study investigated whether…
PurposeAim of this study was to demonstrate that MDCO-216 (human recombinant Apolipoprotein A-I Milano) does not induce adverse…
Reverse lipid transport is critical to maintain homeostasis. Smoking causes lipid accumulation in macrophages, therefore…
Objective— To determine effects of single ascending doses of MDCO-216 on high-density lipoprotein (HDL) subfractions in relation…
Aims Apolipoprotein A-1 (ApoA-1), based on epidemiology, is inversely associated with cardiovascular (CV) events. Human carriers…
MDCO-216 is a complex of dimeric ApoA-IMilano and palmitoyl oleoyl phosphatidylcholine (POPC), previously shown to reduce…
MDCO-216, a complex of dimeric recombinant apoA-IMilano (apoA-IM) and palmitoyl-oleoyl-phosphatidylcholine (POPC), was…