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MDCO-216

National Institutes of Health

Related topics

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3 relations

Broader (3)

Apolipoprotein A-IDrug CombinationsPhosphatidylcholines

Papers overview

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2019
2019
Effective Treatment of Diabetic Cardiomyopathy and Heart Failure with Reconstituted HDL (Milano) in Mice
The risk of heart failure (HF) is prominently increased in patients with type 2 diabetes mellitus. The objectives of this study… 
Highly Cited
2018
Highly Cited
2018
Effect of Infusion of High-Density Lipoprotein Mimetic Containing Recombinant Apolipoprotein A-I Milano on Coronary Disease in Patients With an Acute Coronary Syndrome in the MILANO-PILOT Trial: A…
Importance Infusing a high-density lipoprotein mimetic containing apolipoprotein A-I Milano demonstrated potential atheroma… 
2018
2018
Successful treatment of established heart failure in mice with recombinant HDL (Milano)
The pleiotropic properties of HDL may exert beneficial effects on the myocardium. The effect of recombinant HDLMilano on… 
2018
2018
Reconstituted HDL (Milano) Treatment Efficaciously Reverses Heart Failure with Preserved Ejection Fraction in Mice
Heart failure with preserved ejection fraction (HFpEF) represents a major unmet therapeutic need. This study investigated whether… 
2017
2017
MDCO-216 Does Not Induce Adverse Immunostimulation, in Contrast to Its Predecessor ETC-216
PurposeAim of this study was to demonstrate that MDCO-216 (human recombinant Apolipoprotein A-I Milano) does not induce adverse… 
2017
2017
Interplay between cigarette smoking and pulmonary reverse lipid transport
Reverse lipid transport is critical to maintain homeostasis. Smoking causes lipid accumulation in macrophages, therefore… 
2016
2016
High-Density Lipoprotein Subfractions and Cholesterol Efflux Capacities After Infusion of MDCO-216 (Apolipoprotein A-IMilano/Palmitoyl-Oleoyl-Phosphatidylcholine) in Healthy Volunteers and Stable…
Objective— To determine effects of single ascending doses of MDCO-216 on high-density lipoprotein (HDL) subfractions in relation… 
Highly Cited
2015
Highly Cited
2015
A single infusion of MDCO-216 (ApoA-1 Milano/POPC) increases ABCA1-mediated cholesterol efflux and pre-beta 1 HDL in healthy volunteers and patients with stable coronary artery disease
Aims Apolipoprotein A-1 (ApoA-1), based on epidemiology, is inversely associated with cardiovascular (CV) events. Human carriers… 
2014
2014
Incubation of MDCO-216 (ApoA-IMilano/POPC) with Human Serum Potentiates ABCA1-Mediated Cholesterol Efflux Capacity, Generates New Prebeta-1 HDL, and Causes an Increase in HDL Size
MDCO-216 is a complex of dimeric ApoA-IMilano and palmitoyl oleoyl phosphatidylcholine (POPC), previously shown to reduce… 
2013
2013
Effect of repeated apoA-IMilano/POPC infusion on lipids, (apo)lipoproteins, and serum cholesterol efflux capacity in cynomolgus monkeys[S]
MDCO-216, a complex of dimeric recombinant apoA-IMilano (apoA-IM) and palmitoyl-oleoyl-phosphatidylcholine (POPC), was… 
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