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MDC1 gene

Known as: mediator of DNA damage checkpoint 1, Em:AB023051.5, NFBD1 
This gene plays a role in cell cycle progression.
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
Mammalian cells respond to DNA double-strand breaks (DSBs) by recruiting DNA repair and cell-cycle checkpoint proteins to such… Expand
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Highly Cited
2007
Highly Cited
2007
Cells respond to DNA double-strand breaks by recruiting factors such as the DNA-damage mediator protein MDC1, the p53-binding… Expand
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Highly Cited
2007
Highly Cited
2007
Accumulation of repair proteins on damaged chromosomes is required to restore genomic integrity. However, the mechanisms of… Expand
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Highly Cited
2006
Highly Cited
2006
MDC1 functions in checkpoint activation and DNA repair following DNA damage. To address the physiological role of MDC1, we… Expand
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Highly Cited
2005
Highly Cited
2005
Histone variant H2AX phosphorylation in response to DNA damage is the major signal for recruitment of DNA-damage-response… Expand
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Highly Cited
2004
Highly Cited
2004
Mdc1/NFBD1 controls cellular responses to DNA damage, in part via interacting with the Mre11-Rad50-Nbs1 complex that is involved… Expand
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Highly Cited
2003
Highly Cited
2003
To counteract the continuous exposure of cells to agents that damage DNA, cells have evolved complex regulatory networks called… Expand
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Highly Cited
2003
Highly Cited
2003
MRE11, RAD50 and NBS1 form a highly conserved protein complex (the MRE11 complex) that is involved in the detection, signalling… Expand
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Highly Cited
2003
Highly Cited
2003
Most human somatic cells can undergo only a limited number of population doublings in vitro. This exhaustion of proliferative… Expand
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Highly Cited
2003
Highly Cited
2003
Forkhead-homology-associated (FHA) domains function as protein–protein modules that recognize phosphorylated serine/threonine… Expand
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