MDC1 gene

Known as: mediator of DNA damage checkpoint 1, Em:AB023051.5, NFBD1 
This gene plays a role in cell cycle progression.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1997-2018
010203019972018

Papers overview

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Highly Cited
2009
Highly Cited
2009
A hallmark of the cellular response to DNA double-strand breaks (DSBs) is histone H2AX phosphorylation in chromatin to generate… (More)
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Highly Cited
2008
Highly Cited
2008
The MRE11-RAD50-Nijmegen breakage syndrome 1 (NBS1 [MRN]) complex accumulates at sites of DNA double-strand breaks (DSBs) in… (More)
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Highly Cited
2008
Highly Cited
2008
DNA double-strand breaks (DSBs) trigger accumulation of the MRE11-RAD50-Nijmegen breakage syndrome 1 (NBS1 [MRN]) complex, whose… (More)
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Highly Cited
2008
Highly Cited
2008
The product of the Nijmegen breakage syndrome gene (NBS1) plays crucial roles in DNA damage response through its association with… (More)
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Highly Cited
2008
Highly Cited
2008
Mammalian cells respond to DNA double-strand breaks (DSBs) by recruiting DNA repair and cell-cycle checkpoint proteins to such… (More)
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Highly Cited
2007
Highly Cited
2007
Cells respond to DNA double-strand breaks by recruiting factors such as the DNA-damage mediator protein MDC1, the p53-binding… (More)
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Highly Cited
2006
Highly Cited
2006
MDC1 functions in checkpoint activation and DNA repair following DNA damage. To address the physiological role of MDC1, we… (More)
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Highly Cited
2003
Highly Cited
2003
To counteract the continuous exposure of cells to agents that damage DNA, cells have evolved complex regulatory networks called… (More)
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Highly Cited
2003
Highly Cited
2003
MRE11, RAD50 and NBS1 form a highly conserved protein complex (the MRE11 complex) that is involved in the detection, signalling… (More)
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Highly Cited
2003
Highly Cited
2003
Forkhead-homology-associated (FHA) domains function as protein–protein modules that recognize phosphorylated serine/threonine… (More)
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