MCPH1 wt Allele

Known as: Microcephalin 1 wt Allele, FLJ12847, BRCT-Repeat Inhibitor of TERT Expression 1 Gene 
Human MCPH1 wild-type allele is located in the vicinity of 8p23.1 and is approximately 237 kb in length. This allele, which encodes microcephalin… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2005-2017
01220052017

Papers overview

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2017
2017
DNA double-strand breaks (DSBs) serve as obligatory intermediates for Ig heavy chain (Igh) class switch recombination (CSR). The… (More)
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2015
2015
The DNA damage response (DDR) is crucial for genomic integrity. BRIT1 (breast cancer susceptibility gene C terminus-repeat… (More)
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2015
2015
BRUCE is implicated in the regulation of DNA double-strand break response to preserve genome stability. It acts as a scaffold to… (More)
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2013
2013
In humans, the gene encoding the BRCA1 C terminus-repeat inhibitor of human telomerase expression 1 (BRIT1) protein is located on… (More)
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Highly Cited
2011
Highly Cited
2011
Primary microcephaly 1 is a neurodevelopmental disorder caused by mutations in the MCPH1 gene, whose product MCPH1 (also known as… (More)
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2010
2010
BRIT1 protein (also known as MCPH1) contains 3 BRCT domains which are conserved in BRCA1, BRCA2, and other important molecules… (More)
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Review
2010
Review
2010
Mammalian cells are frequently at risk of DNA damage from both endogenous and exogenous sources. Accordingly, cells have evolved… (More)
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Highly Cited
2009
Highly Cited
2009
To detect and repair damaged DNA, DNA-damage-response proteins need to overcome the barrier of condensed chromatin to gain access… (More)
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Highly Cited
2006
Highly Cited
2006
BRIT1, initially identified as an hTERT repressor, has additional functions at DNA damage checkpoints. Here, we demonstrate that… (More)
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Highly Cited
2005
Highly Cited
2005
BRIT1 [BRCT-repeat inhibitor of hTERT expression], a repressor of human telomerase function, is implicated in cellular… (More)
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