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The bispyridinium compound MB327 has been shown previously to have a positive pharmacological effect against poisoning with… Expand The primary toxic mechanism of organophosphorus compounds, i.e. nerve agents or pesticides, is based on the irreversible… Expand Medical countermeasures for acute poisoning by organophosphorus nerve agents are generally assessed over 24h following poisoning… Expand Irreversible inhibition of the acetylcholine esterase upon intoxication with organophosphorus compounds leads to an accumulation… Expand A novel series of 30 symmetric bispyridinium and related N‐heteroaromatic bisquaternary salts with a propane‐1,3‐diyl linker was… Expand Abstract The potency of the bispyridinium non-oxime compound MB327 [1,1′-(propane-1,3-diyl)bis(4-tert-butylpyridinium) diiodide… Expand Current organophosphorus nerve agent medical countermeasures do not directly address the nicotinic effects of poisoning. A series… Expand Organophosphorous compounds (OP) are highly toxic compounds. Great efforts have been undertaken in the last decades to develop… Expand The standard treatment of poisoning by organophosphorus (OP) nerve agents with atropine and oximes is not sufficiently effective… Expand