MAPKAPK2 protein, human

Known as: MK2 protein, human, MK-2, MAP Kinase-Activated Protein Kinase 2 
MAP kinase-activated protein kinase 2 (400 aa, ~46 kDa) is encoded by the human MAPKAPK2 gene. This protein is involved in stress responsive… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1970-2017
010203019702017

Papers overview

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Highly Cited
2010
Highly Cited
2010
Following genotoxic stress, cells activate a complex kinase-based signaling network to arrest the cell cycle and initiate DNA… (More)
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Highly Cited
2009
Highly Cited
2009
When modeling cell signaling networks, a balance must be struck between mechanistic detail and ease of interpretation. In this… (More)
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Highly Cited
2007
Highly Cited
2007
In response to DNA damage, eukaryotic cells activate ATM-Chk2 and/or ATR-Chk1 to arrest the cell cycle and initiate DNA repair… (More)
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Highly Cited
2007
Highly Cited
2007
MK2 and MK3 represent protein kinases downstream of p38 mitogen-activated protein kinase (MAPK). Deletion of the MK2 gene in mice… (More)
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Highly Cited
2006
Highly Cited
2006
The p38 mitogen-activated protein kinase (MAPK) signaling pathway, acting through the downstream kinase MK2, regulates the… (More)
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Highly Cited
2006
Highly Cited
2006
MAPK-activated protein kinase 2 (MAPKAP K2 or MK2) is one of several kinases directly regulated by p38 MAPK. A role for p38 MAPK… (More)
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Highly Cited
2003
Highly Cited
2003
Tuberous sclerosis complex (TSC) is a genetic disease caused by mutations in either TSC1 or TSC2 tumor suppressor genes. TSC1 and… (More)
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Highly Cited
2003
Highly Cited
2003
The mRNAs of urokinase plasminogen activator (uPA) and its receptor, uPAR, contain instability-determining AU-rich elements (AREs… (More)
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Highly Cited
2001
Highly Cited
2001
Akt activation requires phosphorylation of Thr(308) and Ser(473) by 3-phosphoinositide-dependent kinase-1 and 2 (PDK1 and PDK2… (More)
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Highly Cited
1999
Highly Cited
1999
Stabilization of mRNAs contributes to the strong and rapid induction of genes in the inflammatory response. The signaling… (More)
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