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MAPK-ERK Kinases

Known as: mek, MAP ERK Kinase, Kinases, MAPK-ERK 
National Institutes of Health

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MAP kinase kinase activityMAP kinase kinase kinase activityMAP3K1 geneMAPK-ERK Kinase Kinases

Broader (1)

Mitogen-Activated Protein Kinase Kinases

Papers overview

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2017
2017
L\'{e}vy noise-induced transitions in gene regulatory networks
Important effects of noise on a one-dimensional gene expression model involving a single gene have recently been discussed… 
2017
2017
Abstract 5662: MEK inhibitors potentiate tumor immune surveillance by enhancing cancer cell response of IFNγ
FDA approved mitogen-activated protein kinase (MAPK) kinase (MEK) targeting inhibitors such as trametinib have recently been… 
2016
2016
Differential Regulation of the EMT Axis by MEKl/2 and MEKS in Triple-Negative Breast Cancer
2015
2015
Abstract 2649: Inhibition of mTOR, but not PI3K, is required for the anti-tumor efficacy in breast cancer of dual PI3K/mTOR inhibitors given in combination with MEK inhibitors
Background: The mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin… 
2014
2014
The Activated MEK / ERK Pathway may Potentiate Breast Cancer Resistance Protein / ABCG 2 Function in SN 38-selected MCF-7 Cells
A variant of the breast cancer MCF-7 cells, termed MCF-7/SNR, was established by chronic and step-wise exposure to SN38, an… 
2014
2014
Microenvironment and Immunology Induction of Immunoregulatory CD 271 þ Cells by Metastatic Tumor Cells That Express Human Endogenous Retrovirus H
Human endogenous retroviruses (HERV) are associated with many diseases such as autoimmune diseases and cancer. Although the… 
2006
2006
Effects of moderate hypothermia on p-ERK/p38 MAPK signal pathway following hypoxic-ischemic brain injury in neonatal rats
目的 探讨丝裂原活化蛋白激酶(mitogen-activated protein kinases,MAPK)信号转导通路p-ERK/p38部分活化在亚低温治疗新生大鼠缺氧缺血性脑损伤(hypoxic-ischemic brain damage,HIBD… 
2003
2003
Potent inhibition of MAPK signal through haloperidol metabolites in MEK level: stereospecific effect of p-fluorobenzoic proprionic acid
2001
2001
Cloning and Characterization of Two Distinct Human Extracellular Signal-regulated Kinase Activator Kinases , MEKl and MEK 2 *
Mitogen-induced signal transduction is mediated by a cascade of protein phosphorylation and dephosphorylation. One of the… 
2000
2000
Advances in Brief Transfection of Constitutively Active Mitogen-activated Protein / Extracellular Signal-regulated Kinase Kinase Confers Tumorigenic and Metastatic Potentials to NIH 3 T 3 Cells 1
Cellular growth and differentiation are controlled by multiple extracellular signals, many of which activate extracellular signal…