MAPK-ERK Kinases

Known as: mek, MAP ERK Kinase, Kinases, MAPK-ERK 
 
National Institutes of Health

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Highly Cited
2012
Highly Cited
2012
The RAS/RAF/MEK pathway is activated in more than 30% of human cancers, most commonly via mutation in the K-ras oncogene and also… (More)
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Highly Cited
2009
Highly Cited
2009
Autophagy-essential proteins are the molecular basis of protective or destructive autophagy machinery. However, little is known… (More)
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Highly Cited
2003
Highly Cited
2003
Anthrax lethal toxin produced by the bacterium Bacillus anthracis is the major cause of death in animals infected with anthrax… (More)
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Highly Cited
2002
Highly Cited
2002
Brain-derived neurotrophic factor (BDNF) is implicated in long-term synaptic plasticity in the adult hippocampus, but the… (More)
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Highly Cited
1998
Highly Cited
1998
Gene activation and cellular differentiation induced by interleukin-6 (IL-6) and transcription factor Stat3 are suppressed by… (More)
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Highly Cited
1997
Highly Cited
1997
Mitogens promote cell growth through integrated signal transduction networks that alter cellular metabolism, gene expression and… (More)
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Highly Cited
1996
Highly Cited
1996
Mitogen-activated protein (MAP) kinases require dual phosphorylation on threonine and tyrosine residues in order to gain… (More)
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Highly Cited
1995
Highly Cited
1995
We have identified two components of a new protein kinase signaling cascade, MAPK/ERK kinase 5 (MEK5) and extracellular signal… (More)
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Highly Cited
1994
Highly Cited
1994
Mitogen-activated protein kinases (MAPKs) are rapidly activated in response to stimulation of diverse receptor types. MAPKs are… (More)
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Highly Cited
1993
Highly Cited
1993
Activation of extracellular signal-regulated kinase (ERK) or mitogen-activated protein kinase by MEK (mitogen-activated protein… (More)
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