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MAP3K8 gene

Known as: MEKK8, TPL2, MAP3K8 
This gene is involved in cell growth, survival and proliferation.
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by… Expand
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Highly Cited
2012
Highly Cited
2012
Purpose: The clinical use of BRAF inhibitors is being hampered by the acquisition of drug resistance. This study shows the… Expand
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Highly Cited
2010
Highly Cited
2010
Oncogenic mutations in the serine/threonine kinase B-RAF (also known as BRAF) are found in 50–70% of malignant melanomas. Pre… Expand
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Highly Cited
2008
Highly Cited
2008
Interleukin-6 (IL-6) is overexpressed and contributes to tumor cell growth in cholangiocarcinoma. Enforced IL-6 production can… Expand
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Highly Cited
2006
Highly Cited
2006
Toll-like receptors (TLRs) are a recently described receptor class involved in the regulation of innate and adaptive immunity… Expand
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Highly Cited
2004
Highly Cited
2004
  • Kenji Sugimoto, M. Ohata, +9 authors T. Matsuguchi
  • The Journal of clinical investigation
  • 2004
  • Corpus ID: 5661764
A serine/threonine protein kinase, Cot/Tpl2, is indispensable for extracellular signal-regulated kinase (ERK) activation and… Expand
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Highly Cited
2002
Highly Cited
2002
ABSTRACT The Akt (or protein kinase B) and Cot (or Tpl-2) serine/threonine kinases are associated with cellular transformation… Expand
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Highly Cited
2001
Highly Cited
2001
Cyclooxygenase-2 (COX-2) is induced in human T lymphocytes upon T cell receptor triggering. Here we report that Cot kinase, a… Expand
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Highly Cited
2000
Highly Cited
2000
Tpl2 knockout mice produce low levels of TNF-alpha when exposed to lipopolysaccharide (LPS) and they are resistant to LPS/D… Expand
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Highly Cited
2000
Highly Cited
2000
ABSTRACT The serine/threonine kinase Cot is a member of the mitogen-activated protein kinase (MAPK) kinase kinase family… Expand
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