MAP3K8 gene

Known as: MEKK8, TPL2, MAP3K8 
This gene is involved in cell growth, survival and proliferation.
National Institutes of Health

Papers overview

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2012
2012
This study aimed to explore the inhibitory effect of Celastrus orbiculatus Thunb. (COT) on tumor growth, metastasis and… (More)
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2011
2011
Multiparous ewes received 100% (control, C, n = 13) or 50% (nutrient restricted, NR, n = 14) of NRC dietary requirements from d28… (More)
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Highly Cited
2010
Highly Cited
2010
Oncogenic mutations in the serine/threonine kinase B-RAF (also known as BRAF) are found in 50–70% of malignant melanomas. Pre… (More)
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Highly Cited
2008
Highly Cited
2008
Interleukin-6 (IL-6) is overexpressed and contributes to tumor cell growth in cholangiocarcinoma. Enforced IL-6 production can… (More)
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2008
2008
The MAPKKK8 Cot/tpl-2, identified as an oncogene (Cot-T), participates in the intracellular signaling activated by members of the… (More)
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2007
2007
Tumor necrosis factor (TNF)-receptor-associated-factor-6 (TRAF6) is an adaptor protein involved in Toll-like receptor (TLR… (More)
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2006
2006
The synthesis and structure-activity studies of a series of quinoline-3-carbonitriles as inhibitors of Tpl2 kinase are described… (More)
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2001
2001
Cyclooxygenase-2 (COX-2) is induced in human T lymphocytes upon T cell receptor triggering. Here we report that Cot kinase, a… (More)
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Highly Cited
2000
Highly Cited
2000
Tpl2 knockout mice produce low levels of TNF-alpha when exposed to lipopolysaccharide (LPS) and they are resistant to LPS/D… (More)
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2000
2000
Mitogen-activated protein kinase upstream kinase/dual leucine zipper-bearing kinase/leucine-zipper protein kinase (MUK/DLK/ZPK… (More)
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