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MAP2K1 wt Allele

Known as: MEK1, MKK1, MAPKK1 
Human MAP2K1 wild-type allele is located within 15q22.1-q22.33 and is approximately 104 kb in length. This allele, which encodes mitogen-activated… Expand
National Institutes of Health

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Highly Cited
2012
Highly Cited
2012
UNLABELLED BRAF inhibitors (BRAFi) induce antitumor responses in nearly 60% of patients with advanced V600E/KBRAF melanomas… Expand
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Highly Cited
2009
Highly Cited
2009
Constitutive activation of the MAP kinase kinase MEK1 induces oncogenic transformation in intestinal epithelial cells. Loss of… Expand
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Highly Cited
2008
Highly Cited
2008
Toll-like receptor (TLR)-4 signaling promotes cytokine synthesis in vascular smooth muscle cells (VSMC). However, it is unknown… Expand
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Highly Cited
2007
Highly Cited
2007
Background Among gynecologic cancers, ovarian cancer is the second most common and has the highest death rate. Cancer is a… Expand
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Highly Cited
2004
Highly Cited
2004
Epidermal activation of Erk MAPK is observed in human psoriatic lesions and in a mouse model of psoriasis in which beta1… Expand
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Highly Cited
2004
Highly Cited
2004
The ERK cascade is activated by hormones, cytokines, and growth factors that result in either proliferation or growth arrest… Expand
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Highly Cited
2002
Highly Cited
2002
Extracellular signal-regulated kinases 1 and 2 (ERK1 and ERK2) are essential components of pathways through which signals… Expand
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Highly Cited
1998
Highly Cited
1998
Clonal selection of T lymphocytes is essential for establishing self/non-self discrimination of immune recognition. It is known… Expand
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Highly Cited
1998
Highly Cited
1998
We have previously demonstrated that hydrogen peroxide (H2O2) treatment of bovine tracheal myocytes increases the activity of… Expand
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Highly Cited
1997
Highly Cited
1997
We tested whether activation of mitogen-activated protein kinase/ extracellular signal-regulated kinase kinase-1 (MEK1) is… Expand
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