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M 17055

Known as: M-17055, M17055 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1992-2006
012319922006

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2006
2006
Characterization of the Uptake Mechanism for a Novel Loop Diuretic, M17055, in Caco-2 Cells: Involvement of Organic Anion Transporting Polypeptide (OATP)-B
M17055 is under development as a novel loop diuretic for oral administration. To investigate the molecular mechanism of its… (More)
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2004
2004
Characterization of renal excretion mechanism for a novel diuretic, M17055, in rats.
M17055 was developed as a novel diuretic that inhibits both Na(+), K(+), and 2Cl(-) cotransport at the thick ascending Henle's… (More)
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2002
2002
Studies on the metabolic fate of M17055, a novel diuretic (4): species difference in metabolic pathway and identification of human CYP isoform responsible for the metabolism of M17055.
The metabolic profile of M17055, a novel diuretic, after administration to experimental animals and after incubation with human… (More)
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2002
2002
Studies on the metabolic fate of M17055, a novel diuretic (6). Assessment for drug-drug interactions of M17055 in metabolism, distribution and excretion.
1. The potential of M17055, a novel diuretic candidate, to affect the activities of human CYP enzymes, alter the plasma unbound… (More)
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1996
1996
Molecular effects of M17055, furosemide and thiazide on cardiac hypertrophy of spontaneously hypertensive rats.
Although diuretics have been clinically shown to reduce cardiovascular morbidity and mortality, the effects of diuretics on… (More)
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1993
1993
Loop and distal actions of a novel diuretic, M17055.
We investigated the mechanism of action of a novel 'high ceiling' diuretic, M17055, in in vivo clearance studies with… (More)
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1993
1993
Beneficial effect of a novel diuretic, M17055, on blood pressure and cardiovascular hypertrophy in spontaneously hypertensive rats.
We investigated the effects of a novel diuretic, M17055, on blood pressure and cardiovascular hypertrophy in spontaneously… (More)
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1993
1993
Effects of amiloride and a novel diuretic, 7-chloro-2,3-dihydro-1-(2-methylbenzoyl)-4(1H)-quinolinone-4-oxime-o-su lfonic acid, potassium salt (M17055), on calcium transport in the rabbit connecting…
To elucidate the mechanisms of relative anticalciuric effect of a diuretic, 7-chloro-2,3-dihydro-1-(2-methylbenzoyl)-4(1H… (More)
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1993
1993
Effect of a novel diuretic, 7-chloro-2,3-dihydro-1-(2-methylbenzoyl)-4(IH)-quinolinone-4-oxime-o- sulfonic acid, potassium salt (M17055) on Na+ and K+ transport in the distal nephron segments.
By using an in vitro microperfusion technique, we examined whether a novel loop diuretic, 7-Chloro-2,3-dihydro-1-(2-methylbenzoyl… (More)
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1992
1992
Pharmacological properties of the novel highly potent diuretic 7-chloro-2,3-dihydro-1-(2-methylbenzoyl)-4(1H)-quinolinone 4-oxime-O-sulfonic acid potassium salt.
7-Chloro-2,3-dihydro-1-(2-methylbenzoyl)-4(1H)-quinolinone 4-oxime-O-sulfonic acid potassium salt (M17055, CAS 114417-20-8… (More)
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