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Loss of Chromosome 9q

Known as: del(9q) 
A cytogenetic abnormality that refers to deletion of part of the long arm of chromosome 9. It is associated with the development of acute myeloid… Expand
National Institutes of Health

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Benign Pyriform Fossa NeoplasmBenign Subglottis NeoplasmBenign Supraglottis NeoplasmBenign Thyroid Gland Neoplasm
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Papers overview

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Highly Cited
2010
Highly Cited
2010
Prognostic impact of specific chromosomal aberrations in a large group of pediatric patients with acute myeloid leukemia treated uniformly according to trial AML-BFM 98.
PURPOSE Because cytogenetic data are essential for risk stratification of childhood acute myeloid leukemia (AML), the impact of… Expand
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Highly Cited
2009
Highly Cited
2009
AML with mutated NPM1 carrying a normal or aberrant karyotype show overlapping biologic, pathologic, immunophenotypic, and prognostic features.
Acute myeloid leukemia (AML) with mutated NPM1 usually carries normal karyotype (NK), but it may harbor chromosomal aberrations… Expand
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Highly Cited
2008
Highly Cited
2008
Loss of TLE1 and TLE4 from the del(9q) commonly deleted region in AML cooperates with AML1-ETO to affect myeloid cell proliferation and survival.
Deletions on chromosome 9q are seen in a subset of acute myeloid leukemia (AML) cases and are specifically associated with t(8;21… Expand
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Highly Cited
2007
Highly Cited
2007
New insights into the prognostic impact of the karyotype in MDS and correlation with subtypes: evidence from a core dataset of 2124 patients.
We have generated a large, unique database that includes morphologic, clinical, cytogenetic, and follow-up data from 2124… Expand
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Highly Cited
2006
Highly Cited
2006
The clinical spectrum of adult acute myeloid leukaemia associated with core binding factor translocations.
To better understand the spectrum of adult acute myeloid leukaemia (AML) associated with core binding factor (CBF) translocations… Expand
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2005
2005
Delineation of the minimal commonly deleted segment and identification of candidate tumor-suppressor genes in del(9q) acute myeloid leukemia.
Deletion of the long arm of chromosome 9, del(9q), is a recurring chromosomal aberration in acute myeloid leukemia (AML) that is… Expand
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2005
2005
Del (9q) AML: clinical and cytological characteristics and prognostic implications.
Del (9q) is a recurrent cytogenetic abnormality in acute myeloid leukaemia (AML). We report an analysis of 81 patients with del… Expand
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2005
2005
Acute myeloid leukemia with deletion 9q within a noncomplex karyotype is associated with CEBPA loss-of-function mutations.
To assess the prevalence of mutations in the CEBPA gene, which encodes the myeloid transcription factor CEBPA in specific… Expand
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Highly Cited
1998
Highly Cited
1998
The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties.
Cytogenetics is considered one of the most valuable prognostic determinants in acute myeloid leukemia (AML). However, many… Expand
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Highly Cited
1996
Highly Cited
1996
Fifty-one patients with acute myeloid leukemia and translocation t(8;21)(q22;q22): an additional deletion in 9q is an adverse prognostic factor.
The translocation t(8;21)(q22;q22) occurs in 6 to 12 percent of patients with AML, and usually predicts a good response to… Expand
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