Loperamide Hydrochloride

Known as: Hydrochloride, Loperamide, loperamide hcl, Loperamide Monohydrochloride 
The hydrochloride salt form of loperamide, a synthetic, piperidine derivative and opioid agonist with antidiarrheal activity. Loperamide acts on the… (More)
National Institutes of Health

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Colonic Diseases, FunctionalConstipationDiarrheaDrug Allergy
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Imodium

Papers overview

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2015
2015
Loperamide toxicokinetics: serum concentrations in the overdose setting.
 
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2013
2013
Tolerance develops to the antiallodynic effects of the peripherally acting opioid loperamide hydrochloride in nerve-injured rats
Peripherally acting opioids are potentially attractive drugs for the clinical management of certain chronic pain states due to… (More)
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2009
2009
Human brain imaging and radiation dosimetry of 11C-N-desmethyl-loperamide, a PET radiotracer to measure the function of P-glycoprotein.
UNLABELLED P-glycoprotein (P-gp) is a membrane-bound efflux pump that limits the distribution of drugs to several organs of the… (More)
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2008
2008
P-glycoprotein function at the blood-brain barrier imaged using 11C-N-desmethyl-loperamide in monkeys.
UNLABELLED 11C-Loperamide is an avid substrate for P-glycoprotein (P-gp), but it is rapidly metabolized to 11C-N-desmethyl… (More)
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2008
2008
Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function.
[(11)C]Loperamide has been proposed for imaging P-glycoprotein (P-gp) function with positron emission tomography (PET), but its… (More)
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2007
2007
Treatment of travelers' diarrhea: randomized trial comparing rifaximin, rifaximin plus loperamide, and loperamide alone.
BACKGROUND & AIMS Antimotility agents provide rapid temporary relief of acute diarrhea, whereas antibiotics slowly cure the… (More)
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2004
2004
LC-MS determination and bioavailability study of loperamide hydrochloride after oral administration of loperamide capsule in human volunteers.
The purpose of the present study was to develop a standard protocol for loperamide hydrochloride bioequivalence testing. For this… (More)
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1990
1990
Treatment of traveler's diarrhea with sulfamethoxazole and trimethoprim and loperamide.
In a randomized, double-blind, placebo-controlled trial, 227 US adults with acute diarrhea in Mexico received a single dose of… (More)
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1982
1982
A double-blind crossover study of the effect of loperamide hydrochloride and codeine phosphate on ileostomy output.
Loperamide hydrochloride (4 mg t.d.s.) was compared with codeine phosphate (60 mg t.d.s.) in a double blind crossover study of… (More)
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1979
1979
Human pharmacokinetics and comparative bioavailability of loperamide hydrochloride.
A pharmacokinetic study of the antidiarrheal agent loperamide hydrochloride (Imodium) was conducted in six male subjects. The… (More)
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