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Loperamide Hydrochloride

Known as: Hydrochloride, Loperamide, loperamide hcl, Loperamide Monohydrochloride 
The hydrochloride salt form of loperamide, a synthetic, piperidine derivative and opioid agonist with antidiarrheal activity. Loperamide acts on the… Expand
National Institutes of Health

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Related topics

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Colonic Diseases, FunctionalConstipationDiarrheaDrug Allergy
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Imodium

Papers overview

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Highly Cited
2013
Highly Cited
2013
Behavior of printable formulations of loperamide and caffeine on different substrates--effect of print density in inkjet printing.
The primary goal of the current work was to study the applicability of precision inkjet printing in fabrication of personalized… Expand
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Highly Cited
2010
Highly Cited
2010
P-Glycoprotein Function at the Blood–Brain Barrier in Humans Can Be Quantified with the Substrate Radiotracer 11C-N-Desmethyl-Loperamide
Permeability-glycoprotein (P-gp), an efflux transporter in several organs, acts at the blood–brain barrier to protect the brain… Expand
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Highly Cited
2009
Highly Cited
2009
P-Glycoprotein Function at the Blood–Brain Barrier Imaged Using 11C-N-Desmethyl-Loperamide in Monkeys
11C-Loperamide is an avid substrate for P-glycoprotein (P-gp), but it is rapidly metabolized to 11C-N-desmethyl-loperamide (11C… Expand
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Highly Cited
2008
Highly Cited
2008
Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function.
[(11)C]Loperamide has been proposed for imaging P-glycoprotein (P-gp) function with positron emission tomography (PET), but its… Expand
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Highly Cited
2007
Highly Cited
2007
Treatment of travelers' diarrhea: randomized trial comparing rifaximin, rifaximin plus loperamide, and loperamide alone.
BACKGROUND & AIMS Antimotility agents provide rapid temporary relief of acute diarrhea, whereas antibiotics slowly cure the… Expand
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Highly Cited
2004
Highly Cited
2004
Effect of finite doses of propylene glycol on enhancement of in vitro percutaneous permeation of loperamide hydrochloride.
We hypothesised that the depletion of propylene glycol from topical formulations applied at clinically relevant doses… Expand
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Highly Cited
1990
Highly Cited
1990
Treatment of traveler's diarrhea with sulfamethoxazole and trimethoprim and loperamide.
In a randomized, double-blind, placebo-controlled trial, 227 US adults with acute diarrhea in Mexico received a single dose of… Expand
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Highly Cited
1986
Highly Cited
1986
Comparison of loperamide with bismuth subsalicylate for the treatment of acute travelers' diarrhea.
Loperamide hydrochloride was compared with bismuth subsalicylate for the treatment of acute nondysenteric travelers' diarrhea in… Expand
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Highly Cited
1982
Highly Cited
1982
A double-blind crossover study of the effect of loperamide hydrochloride and codeine phosphate on ileostomy output.
Loperamide hydrochloride (4 mg t.d.s.) was compared with codeine phosphate (60 mg t.d.s.) in a double blind crossover study of… Expand
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1979
1979
Human Pharmacokinetics and Comparative Bioavailability of Loperamide Hydrochloride
A pharmacokinetic study of the antidiarrheal agent loperamide hydrochloride (Imodium) was conducted in six male subjects. The… Expand
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