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Locally Advanced Disease Clinical Trial Setting

Known as: LOCALLY ADVANCED 
A clinical trial or treatment setting in which the therapy of interest is used to treat locally advanced disease.
National Institutes of Health

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CDISC SDTM Treatment Setting TerminologyClinical Data Interchange Standards Consortium Terminology

Papers overview

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2017
2017
Abstract OT1-01-06: PIQHASSO: Open label, non-randomized, multicenter phase 1/2b study investigating safety and efficacy of PQR309 and eribulin combination in patients (pts) with locally advanced (LA…
BACKGROUND: The PI3K/AKT/mTOR (PAT) pathway alteration has been strongly implicated in breast cancer and may contribute to… 
2016
2016
Abstract OT2-01-06: Phase 2 open label, multinational, randomized, parallel design study investigating the efficacy and safety of GTx-024 on metastatic (MET) or locally advanced (LA) ER+/AR+ breast…
Background: Historically, androgens have been utilized for the treatment of BC as the androgen receptor (AR) is the most highly… 
2016
2016
Induction chemotherapy for patients with Locally advanced triple negative breast cancer.
e12573Background: Compared to other breast cancer subtypes, patients (pts) with triple-negative breast cancer (TNBC) have a lower… 
2013
2013
Neoadjuvant chemotherapy with metronomic doxorubicin, cyclophosphamide, and capecitabine in patients with locally advanced (LA) triple-negative breast cancer (TNBC).
e12027 Background: TNBC is associated with aggressive behavior and poor prognosis. It has been shown that patients (pts) with… 
2011
2011
CO14. A pivotal study evaluating efficacy and safety of the hedgehog pathway inhibitor (HPI) vismodegib (GDC-0449) in patients with locally advanced (la) or metastatic (m) basal cell carcinoma (BCC)
Mayo Clinic, Scottsdale, AZ, M.D. Anderson Cancer Center, Houston, TX, Stanford University School of Medicine, Stanford… 
2010
2010
Long-term results from TAX324: A phase III trial of sequential therapy comparing TPF to PF in locally advanced (LA) squamous cell cancer of the head and neck (HNC).
5512 Background: The original TAX 324 study established TPF induction therapy administered prior to carboplatin-based… 
2008
2008
A pilot study of gemcitabine (g), oxaliplatin (o), cetuximab (c) for locally advanced or metastatic pancreatic cancer
15510 Background: Little progress has been made in the treatment of advanced pancreatic cancer (PC). Preclinical data suggest… 
2008
2008
A phase II study of isoflavone, gemcitabine, and erlotinib in locally advanced (LA) or metastatic pancreatic cancer
15540 Background: Preclinical and clinical data suggest that the EGFR/Akt/NF-κB signaling pathways are frequently deregulated in… 
2006
2006
Phase II trial of cisplatin (C), etoposide (E) and radiation (RT) followed by gemcitabine (G) vs G and docetaxel (D) in stage III A/B unresectable non-small cell lung cancer (NSCLC)
7597 Background: SWOG 9504 demonstrated highly promising survival rates for D consolidation after E + C and radiation therapy in… 
2005
2005
5-FU/ folinic acid plus CPT-11 (FOLFIRI.3 regimen) in advanced pancreatic carcinoma (PC): results of an AGEO phase II study
4116 Background: New therapies are clearly needed to improve the prognosis of patients (pts) with advanced PC. The rationale to…