Lipinski's rule of five

Known as: Lipinsky's Rule of Five, Lipinski Rule of 5, Lipinski's Rules of 5 
Lipinski's rule of five also known as the Pfizer's rule of five or simply the Rule of five (RO5) is a rule of thumb to evaluate druglikeness or… (More)
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Topic mentions per year

Topic mentions per year

2000-2017
0102020002017

Papers overview

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2017
2017
Aims: To demonstrate the efficacy of five small molecule compounds for inhibiting the growth of Mycobacterium tuberculosis. To… (More)
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2017
2017
Aims: To synthesize small molecule alkylating compounds and analyze the kinetics of the alkylation in aqueous solution. Determine… (More)
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2017
2017
Aims: To demonstrate the efficacy of several small molecular weight compounds having hydrazide groups, for inhibiting the growth… (More)
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2016
2016
We present three in silico volume of distribution at steady state (VDss) models generated on a training set comprising 1096… (More)
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2015
2015
Background Due to unsatisfactory results of alcohol-related SBI in patients with severe Alcohol Use Disorders (AUDs), many… (More)
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2013
2013
To evaluate the toxic properties of Anti-Alzheimer’s drugs, such as Galantamine hydrobromide, Physosigmine, Rivastigmine… (More)
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2013
2013
Some of the new 10H phenothiazine derivatives had been synthesized for their anti psychotic activity as dopamine antagonists… (More)
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2010
2010
Drug likeness analysis is widely used in modern drug design. However, most drug likeness filters, represented by Lipinski's "Rule… (More)
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2006
2006
Glycogen Synthase Kinase-3 is a regulatory serine/threonine kinase, which is being targeted for the treatment of a number of… (More)
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2003
2003
JANET WOODCOCK CENTER FOR DRUG EVALUATION AND RESEARCH, WASHINGTON, MD, USA Poor pharmacokinetic properties, such as low oral… (More)
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