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Li-Fraumeni Syndrome

Known as: Li-Fraumeni Familial Cancer Susceptibility Syndrome, Li Fraumeni Syndrome, LFS 
Rare autosomal dominant syndrome characterized by mesenchymal and epithelial neoplasms at multiple sites. MUTATION of the p53 tumor suppressor gene… Expand
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Despite its increasing use in experimental and clinical settings, the cellular and molecular mechanisms underlying transcranial… Expand
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Highly Cited
2008
Highly Cited
2008
PURPOSE A clinical testing cohort was used to gain a broader understanding of the spectrum of tumors associated with germline p53… Expand
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Highly Cited
2004
Highly Cited
2004
The p53 tumor suppressor gene is commonly altered in human tumors, predominantly through missense mutations that result in… Expand
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Highly Cited
2004
Highly Cited
2004
Individuals with Li-Fraumeni syndrome carry inherited mutations in the p53 tumor suppressor gene and are predisposed to tumor… Expand
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Highly Cited
2003
Highly Cited
2003
A database has been created to collect information on families carrying a germ-line mutation in the TP53 gene and on families… Expand
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Highly Cited
2003
Highly Cited
2003
A dynamical model based on three coupled ordinary differential equations is introduced which is capable of generating realistic… Expand
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Highly Cited
2001
Highly Cited
2001
To evaluate whether alpha-smooth muscle actin (alpha-SMA) plays a role in fibroblast contractility, we first compared the… Expand
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Highly Cited
1998
Highly Cited
1998
BACKGROUND Li-Fraumeni syndrome is a dominantly inherited disorder characterized by early-onset breast cancer, sarcomas, and… Expand
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Highly Cited
1994
Highly Cited
1994
The entire coding sequence of the p53 gene was analysed for the presence of mutations in 12 families conforming to a restricted… Expand
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Highly Cited
1990
Highly Cited
1990
Familial cancer syndromes have helped to define the role of tumor suppressor genes in the development of cancer. The dominantly… Expand
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